分野紹介
染色体制御分野
発表論文

Takemoto K., Tani N., Takada Y., Fujimura S., Tanno N., Yamane M., Okamura K., Sugimoto M., Araki K., Ishiguro K.  Meiosis-specific C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 to DSBs in mouse meiotic recombination.  Cell Reports 31, 107686 (2020)

https://doi.org/10.1016/j.celrep.2020.107686

 

Nakatake Y, Ko BHS, Sharov A, Wakabayashi S, Murakami M, Sakota M, Chikazawa N, Ookura C, Sato S, Ito N, Ishikawa-Hirayama M, Mak SS, Jakt LM, Ueno T, Hiratsuka K, Matsushita M, Goparaju SK, Akiyama T, Ishiguro K. Oda M, Gouda N, Umezawa A, Akutsu H, Nishimura K, Matoba R, Ohara O, Ko MSH : Generation and profiling of 2,135 human ESC lines for the systematic analyses of cell states perturbed by inducing single transcription factors.  Cell Reports 31, 107655 (2020)

https://doi.org/10.1016/j.celrep.2020.107655

 

Ishiguro K*, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M,  Sugimoto M,  Fujimura S,  Hosokawa M, Chuma S,  Ko S.H.M, Araki K, Niwa H : MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells. Dev. Cell 52(4), 429-445(2020)

https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30011-3

Preview : MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells. Dev Cell 54, 397-398 (2020) https://www.cell.com/developmental-cell/fulltext/S1534-5807(20)30098-8

F1000Prime Recommendation   10.3410/f.737328633.793571169

NewPress記事へ

 

Tanno N, Kuninaka S, Fujimura S, Okamura K, Takemoto K, Araki K, Araki M, Saya H,  Ishiguro K :  Phosphorylation of the Anaphase Promoting Complex activator CDH1/FZR regulates the transition from Meiosis I to Meiosis II in mouse male germ cell bioRxiv/2020/990127 (2020)

doi: https://doi.org/10.1101/2020.03.13.990127

 

 

Takemoto K. *, Imai Y. *(*: equally contributed), Saito K., Kawasaki T., Carlton M.P., Ishiguro K., Sakai N. : Sycp2 is essential for synaptonemal complex assembly, early meiotic recombination and homologous pairing in zebrafish spermatocytes.  PLoS Genet 16(2): e1008640. (2020) (発生研共同利用)

 

Ishiguro K.  The cohesin complex in mammalian meiosis (Review) : Genes Cells. 24(1):6-30. (2019)

 

Hiratsuka K, Monkawa T, Akiyama T, Nakatake Y, Oda M, Goparaju SK, Kimura H, Chikazawa-Nohtomi N, Sato S, Ishiguro K., Yamaguchi S, Suzuki S, Morizane R, Ko BSH, Itoh H, Ko MSK: Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors : Scientific reports 29;9(1):913. (2019) (発生研共同利用)

 

Ida H., Akiyama T., Ishiguro K., Goparaju SK., Nakatake Y., Chikazawa NN., Sato S., Kimura H., Yokoyama Y., Nagino M., Ko MSH., Ko SBH. : Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAsencoding transcription factors: Stem Cell Res Ther. 9, 277(2018)

 

Ishiguro K., Nakatake Y., Chikazawa-Nohtomi N., Kimura H., Akiyama T., Oda M., Ko SBH., Ko MSH. : Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos: In Vitro Cell.Dev.Biol. 53, 179-190 (2017)

 

Ishiguro K., Monti M., Akiyama T., Kimura H., Chikazawa-Nohtomi N., Sakota M., Sato S., Redi CA., Ko SBH., Ko MSH. : Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis : In Vitro Cell.Dev.Biol. 53, 167-178 (2017)

 

Ishiguro K., Watanabe Y. : The cohesin REC8 prevents illegitimate inter-sister synaptonemal complex: EMBO reports 17, 783-784 (2016)

 

(*: equally contributed)*Kim J, *Ishiguro K., Nambu A., Akiyoshi B., Yokobayashi S., Kagami A., Ishiguro T., Pendas A.M., Takeda N., Sakakibara Y., Kitajima T.S., Tanno Y., Sakuno T., Watanabe Y. : Meikin is a conserved regulator of meiosis-I-specific kinetochore function: Nature 517, 466-471 (2015)

 

Kumar R., Ghyselinck N., Ishiguro K., Watanabe Y., Kouznetsova A., Höög C., Strong E., Schimenti J., Daniel K., Toth A., de Massy B.: MEI4: a central player in the regulation of meiotic DNA double strand break formation in mouse: J. Cell Science 128(9), 1800-1811 (2015)

 

Ishiguro K., Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y.: Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes&Development 28, 594-607 (2014)

 

Shibuya H, Ishiguro K, Watanabe Y.: The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis. Nature Cell Biology 16:145-156 (2014)

 

Belzil C., Asada N., Ishiguro K., Nakaya T., Parsons K., Pendolino V., Neumayer G., Mapelli M., Nakatani Y., Sanada K., Nguyen MD. : p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex. Biol.OPEN 8;3(6):475-485 (2014)

 

(*: equally contributed) *Nakaya T., *Ishiguro K., Belzil C., Rietsch A.M., Yu Q., Mizuno S., Bronson R.T., Geng Y., Nguyen M.D., Akashi K., Sicinski P., Nakatani Y. : p600 Plays Essential Roles in Fetal Development., Plos One 8(6): e66269 (2013)

 

Kim J., Ishiguro K., Kudo N., Watanabe Y. Meiosis specific cohesins in mouse embryonic oocytes. Methods in Molecular Biology 957: 47-57. (2012)

 

Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y. : A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J. Cell Biol. 198:165-172 (2012)

 

Ishiguro K., Kim J., Fujiyama-Nakamura S., Kato S., Watanabe Y. A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing: EMBO report 12 : 267-275 (2011)

 

Tanno Y., Kitajima T., Honda T., Ando Y., Ishiguro K., Watanabe Y.: Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres: Genes&Development 24 : 2169-2179 (2010)

 

Kawashima SA, Yamagishi Y, Honda T, Ishiguro K, Watanabe Y. :Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin. Science. 327 : 172-177 (2010)

 

Shim SY., Wang J., Neumayer G., Tran H., Ishiguro K., Sanada K., Nakatani Y., Nguyen MD. : p600 is a Microtubule / Endoplasmic Reticulum-Associated Protein in CNS Neurons : J. Neuroscience 28 : 3604-3614 (2008)

 

Ishiguro K, Watanabe Y.: Chromosome cohesion in mitosis and meiosis J.Cell Science 120 : 367-369 (2007)

 

Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y. :
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 441 : 46-52 (2006)

 

Nakatani Y, Konishi H, Vassilev A, Kurooka H, Ishiguro K, Sawada J, Ikura T, Korsmeyer SJ, Qin J, Herlitz AM. : p600, a unique protein required for membrane morphogenesis and cell survival. Proc Natl Acad Sci USA.;102:15093-15098 (2005)

 

(*: equally contributed) Ogawa H*, Ishiguro K.*, Gaubatz S., Livingston D., Nakatani Y. : A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells, Science 296 : 1132-1136 (2002)

 

Nagawa F., Kodama M., Nishihara T., Ishiguro K., Sakano H.: Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination, Mol. Cell. Biol. 22 : 7217-7225 (2002)

 

Yoshida T., Tsuboi A., Ishiguro K., Nagawa F., Sakano H.: The DNA bending protein, HMG1, is required for correct cleavage of 23bp-recombination signal sequences by RAG proteins in vitro, Int.Immunol. 12 : 101-109 : (2000)

 

(*: equally contributed) Nagawa F.*, Ishiguro K.*, Tsuboi A.*, Yoshida T., Ishikawa A., Takemori T., Otsuka A.J., Sakano H. : Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination, Mol. Cell. Biol. 18 : 655-663(1998)

 

 

邦文総説・著書

 

石黒啓一郎 体細胞分裂と減数分裂における染色体・クロマチン構造の違い ニューサイエンス社 月刊「細胞」5月増刊号Topics from special edition, 52(4),32-37, 2020.

 

石黒啓一郎 生殖細胞の運命決定 ―体細胞分裂から減数分裂への細胞周期の切替え: 実験医学5月号 カレントトピックス, 38(8)1369-1373, 2020.

 

石黒啓一郎 体細胞分裂から減数分裂への切替え機構 日本遺伝学会 遺伝学のパラダイムシフトを目指して (I), 5,(GGS 94,6) 2020.

 

石黒啓一郎, 金智慧、渡邊嘉典: 減数第一分裂に特異的な染色体分配を制御する新規動原体因子MEIKIN: 実験医学Current Topics , vol33, No9, 1427-1431 (2015)

 

石黒啓一郎, 金智慧、渡邊嘉典: 減数第一分裂に特異的な染色体分配の司令塔としてはたらく新規動原体因子MEIKIN: ライフサイエンス新着論文レビュー,大学共同利用機関法人 情報・システム研究機構ライフサイエンス統合データベースセンター, URL:http://first.lifesciencedb.jp/archives/9704 (2015)

 

秋山智彦, 小田真由美, 石黒啓一郎, 洪繁, 洪実: マウスES細胞の染色体安定性を制御するエピゲノム機構: 細胞工学Vol.34 (11), 1052-1056(2015)

 

石黒啓一郎、渡邊嘉典:減数分裂特異的コヒーシンと染色体異数性疾患: 実験医学vol31, No6, 2578-2585 (2013)

 

石黒啓一郎 – 分担執筆 : 分子細胞生物学辞典(第二版), 東京化学同人(2008)

 

北島智也、作野剛士、石黒啓一郎、渡邊嘉典:セントロメアにおける染色体接着の役割とその分子メカニズム、蛋白質・核酸 ・酵素vol.51, 1809-1816 (2006)

 

石黒啓一郎, 坂野 仁: クロマチンと遺伝子機能制御: 第3章-4 抗原受容体遺伝子の再構成とクロマチン構造, Springer-Verlag Tokyo(2003)

 

小川英知, 石黒啓一郎, 中谷喜洋 : G0期における遺伝子封印機構, 実験医学vol 20, No.12, 1898-1990 (2002)

 

石黒啓一郎, 坂野 仁 : 実教出版 生命科学のための基礎シリーズ – 先端技術と倫理 : 第一部 第4章 抗体産生細胞で起こる遺伝子の再編成 : 61-70(2002)

 

石黒啓一郎, 坂野 仁 : 共立出版 生体防御・感染症と免疫:第2章 免疫系における多様性獲得の分子基盤: 12-43 (2001)

 

石黒啓一郎 – 分担執筆 : 免疫学辞典(第二版), 東京化学同人(2001)

 

石黒啓一郎 : 羊土社BioScience用語ライブラリー・免疫(第二版): 第2章「免疫系細胞の分化・成熟」概論:レセプター遺伝子の発現 : 45–47(2000)

 

名川文清, 石黒啓一郎, 坂野 仁 : V(D)J組換えの素過程-RAG/RSS複合体のフットプリント解析, 蛋白質・核酸 ・酵素vol.43, 101-110 (1998)

 

石黒啓一郎, 林 令子, 坂野 仁 : 抗原レセプター遺伝子におけるV(D)J組換えの素過程とその制御, 実験医学vol.15(11), 1246-1253 (1997)

 

石黒啓一郎, 坂野 仁 : 抗原受容体の構造と遺伝子, 医学書院 標準免疫学(第一版): 70–92 (1997)