分野紹介
細胞医学分野
どの種類の筋肉細胞になるかは酵素「LSD1」が調節
ー酵素とホルモンによる、骨格筋の分化と代謝調節メカニズムを解明ー

 

 

細胞の老化を防ぐ酵素「SETD8」を発見
-老化をコントロールできる時代に向けて-

乳がんの治療抵抗性の仕組みを解明
ー難治性・再発性乳がんの新しい診断・治療法に向けてー

 

科学技術振興機構(JST) プレス共同発表」

http://www.jst.go.jp/pr/announce/20150429/index.html

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Nature Communications
Paper ‘FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure’

 

Metabolism: How diet affects energy metabolism

 

DOI: 10.1038/ncomms1755

 

A novel mechanism for explaining how nutrients in the diet affect the energy metabolism in revealed in a paper published in Nature Communications this week. The study, which shows that a specific protein is a nutrient-sensitive regulator of genes involved energy metabolism, could potentially lead to new treatments of metabolic diseases.
Lysine-specific demetyhlase-1 (LSD1) is known to inhibit the activity of genes by chemically modifying DNA-packaging proteins, which makes it more difficult to read out genetic information. A team of Japanese researchers led by Mitsuyoshi Nakao discovered that LSD1 specifically regulates the activity of genes involved in energy and fatty-acid metabolism. They also found that the activity of genes controlled by LSD1 was markedly reduced in fat tissue of obese mice, but could be increased when mice were treated with drugs that inhibit LSD1. The results suggest that this mechanism is involved in the metabolic adaptation of cells in the body to nutrients in the diet.
The authors say that drugs that inhibit LSD1 could be useful for the treatment of metabolic disorders.

 

CONTACT
Mitsuyoshi Nakao ( Kumamoto University , Japan ) 
Tel: +81 96 373 6800; E-mail: mnakao@kumamoto-u.ac.jp