国際先端研究拠点
国立大学法人熊本大学 国際先端研究拠点
“幹細胞を用いた臓器再建と次世代医療・創薬を目指す国際的研究教育拠点”
“International Research Core for Stem Cell-based Developmental Medicine”

 

国際先端研究拠点ホームへ

平成25年度(2013年度)

 

発生医学研究所 腎臓発生分野 西中村 隆一
1. Kaku Y, Ohmori T, Kudo K, Fujimura S, Suzuki S, Evans SM, Kawakami K, and Nishinakamura R*. Islet1 deletion causes mouse kidney agenesis and hydroureter resembling CAKUT. J. Am. Soc. Nephrol. 24: 1242-1249, 2013.
2. Toyoda D, Taguchi A, Chiga M, Ohmori T, and Nishinakamura R*. Sall4 is expressed in the caudal Wolffian duct and the ureteric bud, but dispensable for kidney development. PLoS One 8(6): e68508. 2013.
3. Fujimoto Y, Tanaka SS*, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, and Nishinakamura R*. Homeoprotein Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev. Cell 26: 416-430, 2013.
4. Liu L, Souto J, Liao W, Jiang Y, Li Y, Nishinakamura R, Huang S, Rosengart T, Yang VW, Schuster M, Ma Y, and Yang J*. Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4) -mediated transcriptional repression in hematopoietic stem cells. J. Biol. Chem. 288(48): 34719-34728, 2013.
5. Nishinakamura R* and Sakaguchi M. BMP signaling and its modifiers in kidney development. Pediatr. Nephrol. 29(4): 681-686, 2014.
6. Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, and Nishinakamura R*. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14(1): 53-67, 2014.
7. Murashima A, Akita H, Okaszawa M, Kishigami S, Nakagata N, Nishinakamura R, and Yamada G*. Midline-derived Shh regulated mesonephric tubule formation through the paraxial mesoderm. Dev. Biol.386(1): 216-226, 2014.

 

発生医学研究所 多能性幹細胞分野 粂 昭苑
1. Hakim F, Kaitsuka T, Mohd RJ, Wei FY, Shiraki N, Akagi T, Yokota T, Kume S, Tomizawa K*. High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-Producing Cells. J. Biol. Chem. 289(14):9623-38, 2014.
2. Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, and Ando Y. Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.Stem Cell Res. 12, 574-583, 2014.
3. Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K,Uesugi M and Kume S. VMAT2 identified as a regulator of late-stage beta cell differentiation. Nat. Chem. Biol. 10, 141-148, 2014.
4. Kaitsuka T, Noguchi H, Shiraki N, Kubo T, Wei FY, Hakim H, Kume S, and Tomizawa K. Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors. Stem Cells Transl. Med. 3, 114-27, 2014.
5. Yamazoe T, Shiraki N, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Sasaki Y, Kume K and Shoen Kume. A synthetic nanofibrillar matrix promotes in vitro hepatic differentiation of embryonic stem cells and induced pluripotent stem cells. J. Cell Sci. 126, 5391-5399, 2013.
6. Kawabata M, Ueno T, Tomita J, Kawatani J, Tomoda A, Kume S, Kume K. Temporal organizations of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children. BMC Psychiatry 13:281, 2013.
7. Iwashita H*, Shiraki N*, Sakano D, Shiga M, Sasamoto K, Kume K., and Kume S. Secreted Cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells. PLoS ONE 8(5): e64291, 2013.
8. Ogaki S, Shiraki N, Kume K, Kume S. Wnt and Notch signals guide embryonic stem cell differentiation into the intestinal lineages. Stem Cells 31, 1086-1096, 2013.
9. Katsumoto K and Kume S. The role of CXCL12-CXCR4 signaling pathway in pancreatic development.Theranostics 3, 11-17, 2013.

 

発生医学研究所 細胞医学分野 中尾 光善
1. Sasai N, Saitoh N, Saitoh H, and Nakao M. The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. Plos One 87: e68478, 2013.
2. Hino S, Nagaoka K, and Nakao M. Metabolism-epigenome crosstalk in physiology and diseases. J. Hum. Genet. (Reviews, Special Section on Epigenomics: biological understanding and clinical application) 58: 410-415, 2013.

 

発生医学研究所 幹細胞誘導分野 江良 択実
1. Isono K, Jono H, Ohya Y, Shiraki N, Yamazoe T, Sugasaki A, Era T, Fusaki N, Tasaki M, Ueda M, Shinriki S, Inomata Y, Kume S, and Ando Y. Generation of familial amyloidotic polyneuropathy-specific induced pluripotent stem cells.Stem Cell Res. 12, 574-583, 2014.

2. Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H. Efficient and reproducible myogenic differentiation from human iPS cells: Prospects for modeling Miyoshi Myopathy in vitro. PLos One 8(4):e61540 (2013)
3. Yoshimura N, Motohashi T, Aoki H, Tezuka K, Watanabe N, Wakaoka T, Era T, Kunisada T. Dual origin of melanocytes defined by Sox1 expression and their region-specific distribution in mammalian skin.Dev. Growth Differ. 55, 270-281 (2013)

 

発生医学研究所 分化制御分野 佐々木 洋
1. Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, *Nishinakamura R. (2014) Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53-67.
2. Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, *Sasaki H (2013) Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr. Biol. 23, 1181-1194.
3. Imuta Y, Kiyonari H, Jang CW, Behringer RR, *Sasaki H (2013) Generation of knock-in mice that express nuclear EGFP and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 51, 210-218.

 

視機能病態学分野 谷原 秀信
1. Kameda T, Inoue T, Inatani M, Tanihara H; Japanese Phaco-Goniosynechialysis Multicenter Study Group. Long-term efficacy of goniosynechialysis combined with phacoemulsification for primary angle closure. Graefe’s Archive for Clinical and Experimental Ophthalmology 251: 825-830, 2013.
2. Goto A, Inatani M, Inoue T, Awai-Kasaoka N, Takihara Y, Ito Y, Fukushima M, Tanihara H. Frequency and risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy. Journal of Glaucoma 22: 572-576, 2013.
3. Yamamoto T, Kuwayama Y, Kano K, Sawada A, Shojji N, Study Group for the Japan Glaucoma Society Survey of Bleb-related Infection. Clinical features of bleb-related infection: a 5-year survey in Japan.Acta Ophthalmologica 91: 619-624, 2013.
4. Tanihara H, Inoue T, Yamamoto T, Kuwayama Y, Abe H, Araie M for the K-115 Clinical Study Group. Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115. JAMA Ophthalmology 131: 1288-1295, 2013.
5. Ogata-Iwao M, Inatani M, Takihara Y, Inoue T, Iwao K, Tanihara H. A prospective comparison between trabeculectomy with mitomycin C and phacotrabeculectomy with mitomycin C. Acta Ophthalmologica91: e500-501, 2013.
6. Awai-Kasaoka N, Inoue T, Kameda T, Fujimoto T, Inoue-Mochita M, Tanihara H. Oxidative stress response signaling pathways in trabecular meshwork cells and their effects on cell viability. Molecular Vision 19: 1332-1340, 2013.
7. Haga A, Inatani M, Shobayashi K, Kojima S, Inoue T, Tanihara H. Risk factors for choroidal detachment after trabeculectomy with mitomycin C. Clinical Ophthalmology 7: 1417-1421, 2013.
8. Tanihara H, Inoue T, Yamamoto T, Kuwayama Y, Abe H, Araie M for the K-115 Clinical Study Group. Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. American Journal of Ophthalmology 156: 731-736, 2013.
9. Kato T, Meguro A, Nomura E, Uemoto R, Nomura N, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N. Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population. Eye 27: 979-983, 2013.
10. Yamamoto T, Kuwayama Y, Nomura E, Tanihara H, Mori K; Japan Glaucoma Society Survey of Bleb-related Infection. Changes in visual acuity and intra-ocular pressure following bleb-related infection: the Japan Glaucoma Society Survey of Bleb-related Infection Report 2. Acta Ophthalmologica 91: e420-426, 2013.
11. Inoue T, Kawaji T, Tanihara H. Elevated levels of multiple biomarkers of Alzheimer’s disease in the aqueous humor of eyes with open-angle glaucoma. Investigative Ophthalmology and Visual Science 54: 5353-5358, 2013.
12. Awai-Kasaoka N, Inoue T, Inatani M, Takihara Y, Ogata-Iwao M, Tanihara H. Prognostic factors in trabeculectomy with mitomycin C having history of previous glaucoma surgery. Japanese Journal of Ophthalmology 57: 514-519, 2013.

 

免疫学分野 阪口 薫雄
1. Takamura S, Kajiwara E, Tsuji-Kawahara S, Masumoto T, Fujisawa M, Kato M, Chikaishi T, Kawasaki Y, Kinoshita S, Itoi M, Sakaguchi N, Miyazawa M. Infection of adult thymus with murine retrovirus induces virus-specific central tolerance that prevents functional memory CD8+ T cell differentiation. PLoS Pathog. 2014 10(3):e1003937.
2. Ogiwara H, Yasui F, Munekata K, Takagi-Kamiya A, Munakata T, Nomura N, Shibasaki F, Kuwahara K,Sakaguchi N, Sakoda Y, Kida H, Kohara M. Histopathological evaluation of the diversity of cells susceptible to H5N1 virulent avian influenza virus. Am J Pathol. 2014 184(1):171-83. .
3. Maeda K, Almofty SA, Singh SK, Eid MM, Shimoda M, Ikeda T, Koito A, Pham P, Goodman MF,Sakaguchi N. GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivity. J Immunol. 2013 191(12):6030-9.
4. Rezano A, Kuwahara K, Yamamoto-Ibusuki M, Kitabatake M, Moolthiya P, Phimsen S, Suda T, Tone S, Yamamoto Y, Iwase H, Sakaguchi N. Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival. BMC Cancer. 2013 13:562.
5. Sakurai A, Takayama K, Nomura N, Munakata T, Yamamoto N, Tamura T, Yamada J, Hashimoto M, Kuwahara K, Sakoda Y, Suda Y, Kobayashi Y, Sakaguchi N, Kida H, Kohara M, Shibasaki F. Broad-spectrum detection of H5 subtype influenza A viruses with a new fluorescent immunochromatography system. PLoS One. 2013 8(11):e76753..
6. Silsirivanit A, Araki N, Wongkham C, Vaeteewoottacharn K, Pairojkul C, Kuwahara K, Narimatsu Y, Sawaki H, Narimatsu H, Okada S, Sakaguchi N, Wongkham S. CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma. Cancer Sci. 2013 104(10):1278-84.
7. Singh SK, Maeda K, Eid MM, Almofty SA, Ono M, Pham P, Goodman MF, Sakaguchi N. GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat. Commun. 2013;4:1830.

 

神経分化学分野 太田 訓正
1. Song X, Sato Y, Sekiguchi K, Tanaka H, and *Ohta K. Equarin is involved in cell adhesion via heparin sulfate proteoglycan during lens development. Dev. Dyn. 242, 23-29. (2013)
2. Ninomiya S, Esumi S, Ohta K, Fukuda T, Ito T, Imayoshi I, Kageyama R, Ikeda T, Itohara S, and *Tamamaki N. Amygdala kindling induces nestin expression in the leptomeninges of the neocortex.Neurosc. Res. 75, 121-129. (2013)
3. Mahmud H, Ahmed G, Naser I B, Shinmyo Y, Ito A, Riyadh A, Felemban A, Song X, Ohta K, and *Tanaka H. The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation. Dev. Biol. 374, 58-70. (2013)
4. Ohta K. The role of Tsukushi as an extracellular signaling coordinator. in “New Principles in Developmental Processes” (Eds. Kondoh H. & Kuroiwa A.) Springer Japan (2013)

 

遺伝子機能応用学分野 甲斐 広文
1. Hiraoka N, Arai Y, Takahashi KA, Mazda O, Kishida T, Honjo K, Tsuchida S, Inoue H, Morino S, Suico MA, Kai H, Kubo T. Mild electrical stimulation with heat stimulation increase heat shock protein 70 in articular chondrocyte. J. Orthop. Res. 2013;31(6):894-900.
2. Komatsu K, Lee J, Miyata M, Lim J.H, Jono H, Koga T, Xu H, Yan C, Kai H, Li J.D Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD. Nat. Commun. 2013;4:1684.(国際共同研究論文)
3. Fukuda R, Suico MA, Koyama K, Omachi K, Kai Y, Matsuyama S, Mitsutake K, Taura M, Koga SM, Shuto T and Kai H. Mild Electrical Stimulation at 0.1-ms Pulse Width Induces p53 Protein Phosphorylation and G2 Arrest in Human Epithelial Cells. J. Biol. Chem.2013, 288:16117-16126.
4. Suzuki S, Shuto T, Sato T, Kaneko M, Takada T, Suico MA, Cyr DM, Suzuki H and Kai H. Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter. Sci. Rep. 4, 4258, 2014(国際共同研究論文)

 

微生物薬学分野 大槻 純男
1. Ito S, Matsumiya K, Ohtsuki S, Kamiie J, Terasaki T:Contributions of degradation and brain-to-blood elimination across the blood-brain barrier to cerebral clearance of human amyloid-beta peptide(1-40) in mouse brain. J Cereb Blood Flow Metab.33:1770-7 (2013)
2. Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T:A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice. Fluids Barriers CNS.10:21 (2013)
3. Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T:Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset. J Pharm Sci. (2013)
4. Sakamoto, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T:Quantitative expression of human drug transporter proteins in lung tissues: Analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry. Pharm Sci. (2013)