Kuna M, Dhakal P, Iqbal K, Dominguez EM, Kent LN, Muto M, Moreno-Irusta A, Kozai K, Varberg KM, Okae H, Arima T, Sucov HM, Soares MJ*.
CITED2 is a conserved regulator of the uterine-placental interface.

Proc Natl Acad Sci USA. 120(3):e2213622120 (2023)

 

Kobayashi EH, Shibata S, Oike A, Kobayashi N, Hamada H, Okae H, Arima T*. Genomic imprinting in human placentation.
Reprod Med Biol. 21(1):e12490 (2022)

 

Jeyarajah MJ, Jaju Bhattad G, Kelly RD, Baines KJ, Jaremek A, Yang FP, Okae H, Arima T, Dumeaux V, Renaud SJ*.
The multifaceted role of GCM1 during trophoblast differentiation in the human placenta.

Proc Natl Acad Sci USA. 119(49):e2203071119 (2022)

 

Kobayashi N, Okae H*, Hiura H, Kubota N, Kobayashi EH, Shibata S, Oike A, Hori T, Kikutake C, Hamada H, Kaji H, Suyama M, Bortolin-Cavaille ML, Cavaille J, Arima T*.
The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells.

Nat Commun. 13(1):3071 (2022)

 

Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A*.
Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells.

Genes Dev. 36(1-2):84-102 (2022)

 

Muto M, Chakraborty D, Varberg KM, Moreno-Irusta A, Iqbal K, Scott RL, McNally RP, Choudhury RH, Aplin JD, Okae H, Arima T, Matsumoto S, Ema M, Mast AE, Grundberg E, Soares MJ*.
Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.

Proc Natl Acad Sci USA. 118(50) (2021)

 

Nagai H, Okada M, Nagai Y, Sakuraba Y, Okae H, Suzuki R, Sugimura S*.
Abnormal cleavage is involved in the self-correction of bovine preimplantation embryos.

Biochem Biophys Res Commun. 562:76-82 (2021)

 

Varberg KM, Iqbal K, Muto M, Simon ME, Scott RL, Kozai K, Choudhury RH, Aplin JD, Biswell R, Gibson M, Okae H, Arima T, Vivian JL, Grundberg E, Soares MJ*.
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development.

Proc Natl Acad Sci USA. 118(10) (2021)

 

Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S*.
Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface.

Proc Natl Acad Sci USA. 117(25):14280-91 (2020)

 

Castel G, Meistermann D, Bretin B, Firmin J, Blin J, Loubersac S, Bruneau A, Chevolleau S, Kilens S, Chariau C, Gaignerie A, Francheteau Q, Kagawa H, Charpentier E, Flippe L, Francois-Campion V, Haider S, Dietrich B, Knofler M, Arima T, Bourdon J, Rivron N, Masson D, Fournier T, Okae H, Freour T, David L*.
Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells.

Cell Rep. 33(8):108419 (2020)

 

Cinkornpumin JK, Kwon SY, Guo Y, Hossain I, Sirois J, Russett CS, Tseng HW, Okae H, Arima T, Duchaine TF, Liu W, Pastor WA*.
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome.

Stem Cell Reports. 15(1):198-213 (2020)

 

Jaju Bhattad G, Jeyarajah MJ, McGill MG, Dumeaux V, Okae H, Arima T, Lajoie P, Berube NG, Renaud SJ*.
Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts.

Cell Death Dis. 11(5):311 (2020)

 

Ruengsinpinya L, Murakami T*, Nakamura E, Takahata Y, Hata K, Nakaminami Y, Okae H, Nishimura R*.
G protein subunit beta1 is an important mediator of the late stage of endochondral ossification.

Biochem Biophys Res Commun. 533(1):90-6 (2020)

 

Shibata S, Kobayashi EH, Kobayashi N, Oike A, Okae H, Arima T*.
Unique features and emerging in vitro models of human placental development.

Reprod Med Biol. 19(4):301-13 (2020)

 

Dodo M, Kitamura H, Shima H, Saigusa D, Wati SM, Ota N, Katsuoka F, Chiba H, Okae H, Arima T, Igarashi K, Koseki T, Sekine H, Motohashi H*.
Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.

J Biochem. 165(4):323-34 (2019)

 

Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T*.
Association of four imprinting disorders and ART.

Clin Epigenetics. 11(1):21 (2019)

 

Murakami T*, Ruengsinpinya L, Nakamura E, Takahata Y, Hata K, Okae H, Taniguchi S, Takahashi M, Nishimura R*.
Cutting Edge: G Protein Subunit beta 1 Negatively Regulates NLRP3 Inflammasome Activation.

J Immunol. 202(7):1942-7 (2019)

 

Takahashi S, Okae H*, Kobayashi N, Kitamura A, Kumada K, Yaegashi N, Arima T*.
Loss of p57(KIP2) expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells.

Proc Natl Acad Sci USA. 116(52):26606-13 (2019)

 

Okae H*, Toh H, Sato T, Hiura H, Takahashi S, Shirane K, Kabayama Y, Suyama M, Sasaki H, Arima T*.
Derivation of Human Trophoblast Stem Cells.

Cell Stem Cell. 22(1):50-63 e6 (2018)

 

Hiura H, Hattori H, Kobayashi N, Okae H, Chiba H, Miyauchi N, Kitamura A, Kikuchi H, Yoshida H, Arima T*.
Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer.

Clin Epigenetics. 9:79 (2017)

 

Kobayashi N, Miyauchi N, Tatsuta N, Kitamura A, Okae H, Hiura H, Sato A, Utsunomiya T, Yaegashi N, Nakai K, Arima T*.
Factors associated with aberrant imprint methylation and oligozoospermia.

Sci Rep. 7:42336 (2017)

 

Sugimura S*, Kobayashi N, Okae H, Yamanouchi T, Matsuda H, Kojima T, Yajima A, Hashiyada Y, Kaneda M, Sato K, Imai K, Tanemura K, Arima T, Gilchrist RB*.
Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence.

Sci Rep. 7(1):6815 (2017)

 

Hamada H, Okae H*, Toh H, Chiba H, Hiura H, Shirane K, Sato T, Suyama M, Yaegashi N, Sasaki H, Arima T*.
Allele-Specific Methylome and Transcriptome Analysis Reveals Widespread Imprinting in the Human Placenta.

Am J Hum Genet. 99(5):1045-58 (2016)

 

Kobayashi N, Okae H, Hiura H, Chiba H, Shirakata Y, Hara K, Tanemura K, Arima T*.
Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa.

PLoS One. 11(11):e0167127 (2016)

 

Okae H*, Arima T.
DNA methylation dynamics during early human development.

J Mamm Ova Res. 323:2 (2016)

 

Stunnenberg HG*, International Human Epigenome C, Hirst M. (著者の一人)
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.

Cell. 167(7):1897 (2016)

 

Okae H, Chiba H, Hiura H, Hamada H, Sato A, Utsunomiya T, Kikuchi H, Yoshida H, Tanaka A, Suyama M, Arima T*.
Genome-wide analysis of DNA methylation dynamics during early human development.

PLoS Genet. 10(12):e1004868 (2014)

 

Kitamura A, Miyauchi N, Hamada H, Hiura H, Chiba H, Okae H, Sato A, John RM, Arima T*.
Epigenetic alterations in sperm associated with male infertility.

Congenit Anom (Kyoto). 55(3):133-44 (2015)

 

Okae H, Matoba S, Nagashima T, Mizutani E, Inoue K, Ogonuki N, Chiba H, Funayama R, Tanaka S, Yaegashi N, Nakayama K, Sasaki H, Ogura A, Arima T*.
RNA sequencing-based identification of aberrant imprinting in cloned mice.

Hum Mol Genet. 23(4):992-1001 (2014)

 

Hiura H, Okae H, Chiba H, Miyauchi N, Sato F, Sato A, Arima T*.
Imprinting methylation errors in ART.

Reprod Med Biol. 13(4):193-202 (2014)

 

Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T*.
Stability of genomic imprinting in human induced pluripotent stem cells.

BMC Genet. 14:32 (2013)

 

Chiba H, Hiura H, Okae H, Miyauchi N, Sato F, Sato A, Arima T*.
DNA methylation errors in imprinting disorders and assisted reproductive technology.

Pediatr Int. 55(5):542-9 (2013)

 

Hiura H, Okae H, Kobayash H, Miyauchi N, Sato F, Sato A, Suzuki F, Nagase S, Sugawara J, Nakai K, Yaegashi N, Arima T*.
High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method.

BMC Med Genomics. 5:8 (2012)

 

Hiura H, Okae H, Miyauchi N, Sato F, Sato A, Van De Pette M, John RM, Kagami M, Nakai K, Soejima H, Ogata T, Arima T*.
Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies.

Hum Reprod. 27(8):2541-8 (2012)

 

Okae H, Hiura H, Nishida Y, Funayama R, Tanaka S, Chiba H, Yaegashi N, Nakayama K, Sasaki H, Arima T*.
Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression.

Hum Mol Genet. 21(3):548-58 (2012)

 

Sato A, Hiura H, Okae H, Miyauchi N, Abe Y, Utsunomiya T, Yaegashi N, Arima T*.
Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis.

Fertil Steril. 95(1):129-34, 34 e1-4 (2011)

 

Okae H, Iwakura Y*.
Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.

Dev Dyn. 239(4):1089-101 (2010)