和文総説は こちら
Niwa, H., Yamamura, K.-I. and Miyazaki, J.-I.: Efficient selection for high-expression transfectants with a novel eukaryotic vector, Gene, 108, 193-200, 1991.
Niwa, H., Araki, K., Kimura, S., Taniguchi, S.-I., Wakasugi, S. and Yamamura, K.-I.: An efficient gene-trap method using poly A trap vectors and characterization of gene-trap events, J. Biochem., 113, 343-349, 1993.
Niwa, H., Burdon, T., Chambers, I. and Smith, A.: Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3, Genes & Dev., 12, 2048-2060, 1998.
Niwa, H.*, Miyazaki, J.-I. and Smith, A. G.*: Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells, Nat. Genet., 24, 372-376, 2000.
Niwa, H.*, Masui, S., Chambers, I., Smith, A. G. and Miyazaki, J.-I.: Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells., Mol. Cell. Biol., 22, 1526-1536, 2002.
Ogawa, K., Matsui, H., Ohtsuka, S. and Niwa, H.*: A novel mechanism for regulating clonal propagation of mouse ES cells. Genes Cells, 9, 471-7, 2004.
Masui, S., Shimosato, D., Toyooka, Y., Yagi, R., Takahashi, K. and Niwa, H.: An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit. Nucleic Acids Res., 33, e43, 2005.
Niwa, H.*, Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R. and Rossant, J.: Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell, 123, 917-929, 2005.
Ogawa, K., Nishinakamura, R., Iwamatsu, Y., Shimosato, D. and Niwa, H.*: Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells. Biochem. Biophys. Res. Commun., 343, 159-166, 2006.
Nakatake, Y., Fukui, N., Iwamatsu, Y., Masui, S., Takahashi, K., Yagi, R., Yagi, K., Miyazaki, J.-I., Matoba, R., Ko, M.S.H. and Niwa, H.*: Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol. Cell. Biol., 26, 7772-7782, 2006.
Matoba, R., Niwa, H., Masui, S., Ohtsuka, S., Garter, M.G., Sharov, A.A. and Ko, M.S.H.: Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling. PLoS One,1, e26, 2006.
Ogawa, K., Saito, A., Matsui, H., Suzuki, H., Ohtsuka, S., Shimosato, D., Morishita, Y., Watabe, T., Niwa, H.* and Miyazono, K.*: Activin/Nodal signaling is involved in propagation of mouse embryonic stem cells. J. Cell Sci., 120, 55-65, 2007.
Masui, S.*, Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A., Ko, M.S.H. and Niwa, H.*: Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat. Cell. Biol., 9, 625-635, 2007.
Shimosato, D., Shiki, M. and Niwa, H.*: Extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells. BMC Dev. Biol.,7, 80, 2007.
Toyooka, Y.*, Shimosato, D., Murakami, K. and Niwa, H.*: Identification and characterization of subpopulations in undifferentiated ES cell culture. Development, 135, 909-918, 2008.
Masui, S., Ohtsuka, S., Yagi, R., Takahashi, K., Ko, M.S.H. and Niwa, H.*: Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells. BMC Dev. Biol., 8, 45, 2008.
Niwa, H.*, Sekita, Y., Tsend-Ayush, E. and Grützner, F.: Platypus Pou5f1 reveals the first steps in the evolution of trophectoderm differentiation and pluripotency in mammals. Evolution & Development, 10, 671-682, 2008.
Sharov, A.A., Masui, S., Sharova, L.V., Piao, Y., Aiba, K., Matoba, R., Xin, L., Niwa, H. and Ko, M.S.: Identification of Pou5f1, Sox2 and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. BMC Genomics, 9, 269, 2008.
Niwa, H.*, Ogawa, K., Shimosato, D. and Adachi, K.: A parallel circuit of LIF signaling pathways maintains pluripotency of mouse ES cells. Nature, 460, 118-122, 2009. DOI: 10.1038/nature08113.
Kitajima, H. and Niwa, H.*: Clonal expansion of human pluripotent stem cells on gelatin-coated surface. Biochem Biophys Res Commun, 396, 933-938, 2010. DOI: 10.1016/j.bbrc.2010.05.026.
Murakami, K., Araki, K., Ohtsuka, S., Wakayama, T. and Niwa, H.*: Choice of random rather than imprinted X inactivation in female ES cell-derived extra-embryonic cells. Development,138, 197-202, 2011. DOI:10.1242/dev.056606.
Martello, G., Sugimoto, T., Diamanti, E., Joshi, A., Hannah, R., Ohtsuka, S., Gottgens, B.*, Niwa, H.* and Smith, A.*: Esrrb is a pivotal target of the GSK3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell, 11, 491-504, 2012. DOI:10.1016/j.stem.2012.06.008.
Ohtsuka, S., Nishikawa-Torikai, S. and Niwa, H.*: E-cadherin promotes incorporation of mouse epiblast stem cells into normal development. PLoS One, 7, e45220, 2012. DOI:10.137/journal.pone.0045220.
Oda, M., Kumaki, Y., Shigeta, M., Jakt, L.M., Matsuoka, C., Yamagiwa, A., Niwa, H. and Okano, M.*: DNA methylation restricts lineage-specific functions of transcription factor Gata4 during embryonic stem cell differentiation. PLoS Genet, 9(6), e1003574, 2013. DOI: 10.1371/journal.pgen.1003574.
Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. and Niwa, H.*: Kinetics of drug selection systems in mouse embryonic stem cells. BMC Biotechnol, 13, 64, 2013. DOI: 10.1186/1472-6750-13-64.
Adachi, K., Nikaido, I., Ohta, H., Ohtsuka, S., Ura, H., kadota, M., Wakayama, T., Ueda, H.R. and Niwa, H.*: Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Mol Cell, 52, 380-392, 2013. DOI org/10.1016/l.molcel.2013.09.002.
Shigeta, M., Ohtsuka, S., Nishikawa-Torikai, S., Yamane, M., Fujii, S., Murakami, K. and Niwa, H.*: Maintenance of pluripotency in mouse ES cells without Trp53. Sci Rep, 3: 2944, 2013 DOI: 10.1038/srep02944.
Ito, S., Yamane, M., Ohtsuka, S. and Niwa, H.: The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 in mouse embryonic stem cells. FEBS Letters, 588, 1128-1135, 2014. DOI:10.1016/j.febslet.2014.02.033.
Ohtsuka, S. and Niwa, H.: The differential activation of intracellular signaling pathways confers the permissiveness of embryonic stem cell derivation from different mouse strains. Development, 142, 431-437, 2015. DOI; 10.1242/dev.112375.
Fujii, S., Nishikawa-Torikai, S., Futatsugi, Y., Toyooka, Y., Yamane, M., Ohtsuka, S. and Niwa, H.: Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. Sci Rep, 16;5;9146, 2015. Doi: 10.1038/srep09146.
Kinoshita, M., Shimosato, D., Yamane, M. and Niwa, H.*: Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells BMC Dev Biol, 15, 37, 2015. Doi: 10.1186/s12861-015-0079-4.
Yamane, M., Fujii, S., Ohtsuka, S. and Niwa, H.*: Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells. Biochem Biophys Res Commun, 468, 826-831, 2015. Doi 10.1016/j.bbrc.2015.11.039
Nakai-Futatsugi, Y. and Niwa, H.: Zscan4 is activated after telomere shortening in mouse embryonic stem cells. Stem Cell Reports, 6, 1-13, 2016. Doi 10.1016/j.stemcr.2016.02.010.
（英文総説）
Niwa, H.*: How is pluripotency determined and maintained? Development, 134, 635-646, 2007.
Niwa, H.*: Mouse ES cell culture system as a model of development. Dev Growth Differ, 52, 275-283, 2010. DOI:10.1111/j.1440-169X.2009.01166.x.
Niwa, H.: The pluripotency transcription factor network at work in reprogramming. Curr Opin Genet Dev, 28C, 25-31, 2014 DOI:10.1016/j.gde.2014.08.004. (review)
Niwa, H.*: Open conformation chromatin and pluripotency. Genes Dev., 21, 2671-2676, 2007. (perspective)
Niwa, H.: Wnt: What’s Needed To maintain pluripotency? Nat Cell Biol, 13, 1024-1025, 2011. (NEWS AND VIEWS) DOI:10.1038/ncb2333.
Nakai-Futatsugi, Y. and Niwa, H.: Epiblast and primitive endoderm differentiation: fragile specification ensures stable commitment. Cell Stem Cell, 16, 346-347, 2015. Doi: 10.1016/j.stem.2015.03.005. (preview)
Niwa, H.: A stepping stone to pluripotency. Cell, 163, 1570-1572, 2015. Doi : 10.1016/j.cell.2015.12.011.(preview)
（主要和文総説）
丹羽仁史：マウスＥＳ細胞の多能性を維持するシグナルー転写因子ネットワーク、実験医学、29, 9-14, 2011.
丹羽仁史：幹細胞の多能性を規定する分子機構、領域総合レビュー、１、e008、2012 DOI: 10.7875/leading.author.1.e008
丹羽 仁史：再生医療の基盤となる転写因子ネットワークに関する基礎知識、再生医療、13, 150-154, 2014.
