Date: March 27, 16:00～17:00 (平成29年3月27日（月）)
Venue: Conference room, 1st floor, IMEG (発生医学研究所１階カンファレンス室)
Moyamoya disease is a cryptogenic and life-threatening cerebrovascular disorder with unique pathologies. Most patients are concentrated in East Asian countries, and some show family history, suggesting significant contribution of genetic factor. We isolated its prominent susceptibility gene mysterin (also known as RNF213) in 2011 (1), of which C-terminal mutation elevates the risk of the disease by over a hundred times. Mysterin gene encodes a very large (591 kDa) protein harboring two mechanical ATPase (AAA+) modules and a ubiquitin ligase domain. We have elucidated several unique features of this protein in vitro and in vivo (1-4) and would like to discuss them and its potential biological relevance at the seminar.
References
1. #Liu W, #Morito D et al., PLoS One. 2011;6(7):e22542.
2. Morito D et al., Sci Rep. 2014 Mar 24;4:4442.
3. Kotani Y, *Morito D et al., Sci Rep. 2015 Nov 4;5:16161.
4. Kotani Y, *Morito D et al., Sci Rep. 2017 Mar 9;7:44293.
森戸博士は、今年度「発生医学の研究拠点」事業の共同研究課題に採択されています。
多数のご来聴を歓迎します。
連絡先：分子細胞制御分野 小椋 光（内線6578）
