イベント&セミナー

[発生研セミナー] 12/19 Dr.Kenjiro Adachi

2017.12.13 ●セミナー

The 321th IMEG Seminar

 

 

【Date】 Dec. 19 (Tue), 2017 15:00~16:00

【Venue】Conference room, 1st floor,
Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University

 

【Title】“Unlocking silenced enhancers for reprogramming to naïve pluripotency” 

 

【Speaker】 Kenjiro Adachi
Department of Cell and Developmental Biology
Max Planck Institute for Molecular Biomedicine

 

 

【Abstract】
Transcription factor-mediated reprogramming to pluripotency is a slow and inefficient process, because most transcription factors fail to access relevant target sites in a refractory chromatin environment. Until now it was unclear how reprogramming factors actually orchestrate the opening of repressive chromatin during the long latency period. We have developed a very efficient and synchronized system for reprogramming mouse epiblast stem cells to naïve pluripotent stem cells, and analyzed the hierarchical relationship of transcription factor and coactivator binding and epigenetic remodeling. Our results reveal the pioneering role of a single reprogramming factor in accessing inactive enhancers containing hypermethylated DNA and driving rapid remodeling of local chromatin structure, highlighting the remarkable plasticity of stable epigenetic information.

 

【Contact】Hitoshi Niwa, Dept of Pluripotent Stem Cell Biology (Ext. 6620)

 

共催: 熊本大学国際先端研究拠点、共同利用・共同研究拠点「発生医学の共同研究拠点」、トランスオミクス医学研究拠点ネットワーク形成事業