Title:
Introducing our strategy to characterize the mechanisms of antimicrobial drug synergy and antagonism.
Speaker:
Yusuke Minato
Associate Professor,
Division of Anti-Infective Drug Discovery, Center for Infectious Disease Research
Fujita Health University
Abstract:
Some antimicrobial drugs are more effective than expected when combined (synergy), while others are less effective (antagonism). Combining synergistic antimicrobial drugs could potentially prevent the emergence of drug-resistant bacteria, and side effects could be reduced because antimicrobial drugs can be prescribed at lower doses. However, the mechanisms by which antimicrobial drugs exhibit synergy and antagonism are not fully understood. Thus, it is difficult to identify new antimicrobial drugs that synergize with existing ones. We previously revealed the mechanism of synergy between the two antimicrobial drugs, sulfamethoxazole and trimethoprim (1). In this presentation, I will present our research strategy for characterizing the mechanisms of antimicrobial drug synergy and antagonism.
Reference:
Mutual Potentiation Drives Synergy between Trimethoprim and Sulfamethoxazole. Nature communications. 9:1003, 2018.
