Living with the past-how early-life diet impact longevity-

 

Fumiaki Obata

Team Leader, RIKEN Center for Biosystems Dynamics Research

Visiting Associate Professor, Graduate School of Biostudies, Kyoto University

 

Recent epidemiological and experimental biological studies have suggested that dietary environments experienced transiently in early life stages, including during development and growth, can increase the risk of various age-related conditions. Development under specific nutritional environments irreversibly shapes a metabolic and physiological state, which may ultimately extend or shorten lifespan. However, it remains largely unknown which nutrients, at what stages, regulate lifespan and through what molecular mechanisms. Using the fruit fly, a model organism with a short life cycle and abundant genetic and dietary tools, we found how early-life environmental conditions influence lifespan. During the process of analyzing these mechanisms in detail, we found that non-essential amino acid tyrosine during the larval stage and methionine during early adulthood strongly impact lifespan. In this presentation, I will introduce our findings on amino acid biology using fruit flies and discuss the relationship between early-life amino acid intake and lifespan.

 

References:

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Hina Kosakamoto et al., Nature Communications 14, 7832, 2023

Hina Kosakamoto et al., Nature Metabolism 4, 944-959, 2022

Hina Kosakamoto et al., Cell Reports 32, 107938, 2020

Fumiaki Obata et al., Developmental Cell 44, 741-751.e3, 2018

Fumiaki Obata et al., Nature Communications 9, 975, 2018

Fumiaki Obata and Masayuki Miura. Nature Communications 6, 8332, 2015

Fumiaki Obata et al., Cell Reports 7, 821-833, 2014