Title:
Hematopoietic Stem Cells in Native and Mailgnant Hematopoiesis

 

Speaker:
David BRYDER
Division of Molecular Hematology, Institution for Laboratory Medicine
Lund University, 221 84 Lund, Sweden
Phone: +46462223951
E-mail: David.Bryder@med.lu.se

 

Abstract:
Hematopoietic Stem Cells (HSCs) have for decades been recognized as the fundamental units of hematopoietic regeneration. While this property is used extensively in the form of bone marrow transplantation for a number of malignancies that involve the hematopoietic system, recent data focusing on the study of native hematopoiesis, including the impact of age on HSC function, has challenged several historical concepts by suggesting little or only minimal contribution of HSCs in steady state. I will describe and present data from the use of transgenic models that allow for the study of HSC proliferation history and progeny precursor relationships in adult mice. As a second part of my talk, I will discuss the implications of HSC and progenitor cell hierarchies for leukemia-initiation.

 

Representative Publications:
1) Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate.. Wahlestedt M, Erlandsson E, Kristiansen T, Lu R, Brakebusch C, Weissman IL, Yuan J, Martin-Gonzalez J, Bryder D. Nat Commun. 2017 Feb 22;8:14533.

2) Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis. Säwén P, Lang S, Mandal P, Rossi DJ, Soneji S, Bryder D. Cell Rep. 2016 Mar 29;14(12):2809-18.

3) Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation. Ugale A, Norddahl GL, Wahlestedt M, Säwén P, Jaako P, Pronk CJ, Soneji S, Cammenga J, Bryder D. Cell Rep. 2014 Nov 20;9(4):1246-55.