Title:
Molecular Pathological Epidemiology of Colorectal Cancer for Personalized Medicine
Shuji Ogino, MD, PhD, MS (Epidemiology)
Associate Professor of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women ‘ s Hospital
Abstract:
Cancers are complex multifactorial diseases caused by interactions of genetic, epigenetic and environmental factors. I have established “Molecular Pathological Epidemiology (MPE)” (Ogino et al. J Natl Cancer Inst 2010; Gut 2011; Nat Rev Clin Oncol 2011) to dissect complex interrelationship between dietary and lifestyle factors, genetic and epigenetic alterations, and tumor behavior. We are utilizing a unique database of two large U.S. nationwide prospective cohort studies, the Nurses’ Health Study (N=121,000 followed since 1976) and the Health Professionals Follow-up Study (N=51,500 followed since 1986). Our discoveries by the novel MPE approach include (to mention just several): interactions between aspirin use and PTGS2 (COX-2) expression levels in colorectal cancer (New Engl J Med 2007; JAMA 2009); one-carbon metabolism and epigenomic (LINE-1) alterations (J Natl Cancer Inst 2008; Gut 2010); the relationship between obesity (host energetics) and FASN expression level in colorectal cancer (J Clin Oncol 2008; J Natl Cancer Inst 2012); interactions between host energetics and CTNNB1 activation in colorectal cancer (JAMA 2011). A better understanding of heterogeneity of carcinogenic process will further contribute to personalized prevention as well as personalized treatment strategy.
References:
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2.Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S. A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology 2009;137:1609-1620.
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4.Ogino S, Chan AT, Fuchs CS, Giovannucci E. Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field [review]. Gut 2011;60:397-411.
5.Ogino S, Galon J, Fuchs CS, Dranoff G. Cancer immunology ? integrated analysis of host and tumor factors for personalized medicine [review]. Nat Rev Clin Oncol 2011:8:711-719.
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