Characterization of exosomes, endogenous nano-particles

 

Rikinari HANAYAMA, MD & PhD
Professor, WPI Nano Life Science Institute (NanoLSI) &
Department of Immunology, Graduate School of Medical Sciences,
Kanazawa University

 

Abstract:
Exosomes are secreted small membrane vesicles, composed of a lipid bilayer with inserted transmembrane proteins, enclosing cytosolic components derived from the exosome-producing cells. Recently, exosomes have received much attention as messengers of intercellular communication networks, allowing the exchange of proteins and lipids between the exosome-producing cells and target cells to trigger various cellular responses. Exosomes were also shown to carry mRNAs and microRNAs inside them, raising the possibility that exosomes transfer genetic information between cells. However, it is not clear whether these processes occur under physiological conditions. Therefore, our lab is aimed at clarifying physiological and pathophysiological functions of exosomes and their secretory mechanisms.

 

Key publications:
1. Int J Cancer. in press
2. Nano Lett. 20(9):6320-8, 2020
3. Carcinogenesis. 41(9):1238-45, 2020
4. JCI Insight. 3(8):e99680, 2018
5. EBioMedicine. 22:89-99, 2017
6. Sci Rep. 6:33935, 2016
7. Sci Rep. 5:7989, 2015