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リエゾンラボ研究会
発表内容

Title:

The roles of cytokines/chemokines in tissue repair

 

Speakers:

Toshikazu Kondo

Department of Forensic Medicine, Wakayama Medical University

 

Abstract

Tissue repair in every organ is one of the most important biological phenomena. Skin wound healing is a representative tissue repair process being composed of three phases: inflammation, proliferation, and maturation. These phases proceed with well-organized interaction between extracellular matrices and epithelia, endothelia and immune cells. We are focusing on the molecular We are focusing on the molecular mechanism of skin wound healing from the aspects of cytokines and chemokines (1-4). In particular, we found that CC chemokine receptor 5 (CCR5) was essential for the recruitment of endothelial progenitor cells and eventual angiogenesis in skin wound healing (5). Thrombus formation/resolution is pathophysiologically similar to skin wound healing. In WT mice, intrathrombotic IFN-γ levels were elevated progressively, and thrombus size was substantially smaller in the absence of IFN-γ, indicating that IFN-γ can have detrimental roles in thrombus resolution (6). Fibrosis is abnormal tissue repair, resulting in loss of functions in every organ. Fibrocytes derived from bone marrow play important roles in tissue fibrosis. We clarified that CX3C chemokine receptor 1 (CX3CR1)-mediated signals were indispensable for fibrocyte recruitment in the development of bleomycin-induced pulmonary fibrosis (7). Furthermore, we are proceeding research projects of cardiovascular diseases such as cardiac hypertrophy and aortic aneurysm/dissection.

 

References

  1. FASEB J 2002; 16(9): 963–974.
  2. J Leukoc Biol 2003; 73(6): 713–721.
  3. J Immunol 2004; 172(3): 1848–1855.
  4. J Immunol 2006; 176(9): 5598–5606.
  5. J Clin Invest. 2012;122(2):711-21.
  6. J Clin Invest. 2011;121(7):2911-20
  7. Sci Rep. 2017;7(1):16833