Speaker：Leqian Yu  (professor, Institute of Zoology, Chinese Academy of Sciences)

Title: Embryo 3D reconstruction and embryo models: get a glimpse of the human gastrulation

Abstract: The extreme scarcity of human embryo samples, combined with the significant differences between traditional model organisms, such as mice, and human early development, results in limited understanding of human embryonic development, particularly from implantation to gastrulation. This has led to what is referred to as the developmental “black box.” Stem cell-based embryo models offer a potential solution for exploring developmental events during this period. However, challenges remain in model development. Our study focuses on two key areas: 1) creating a developmental blueprint through 3D digital reconstruction of human embryos, and 2) simulating the developmental environment by constructing an artificial uterus system. These efforts aim to optimize the creation and development of embryo models, thereby enhancing our understanding of human early development.

Cell 2026, 2025, 2024, 2023,

Nature 2021, Cell Stem Cell 2025, 2023, 2020   http://english.ioz.cas.cn/staff/en/leqianyu.html