招聘者: 野村 征太郎 東京大学大学院医学系研究科 先端循環器医科学講座 特任准教授
Seitaro Nomura Project Associate Professor, Graduate School of Medicine, The University of Tokyo
– 講演タイトル
Integrated Understanding of Biological Systems for Disease Control
– 抄録
Biological phenomena are dynamic systems shaped through the interaction between genetic and environmental factors. In this lecture, using cardiovascular disease as a model, I will present a new research framework that integrates genomics, single-cell and spatial omics, and clinical phenotypes to elucidate disease mechanisms at the molecular level and achieve a systems-level understanding of biological processes. Furthermore, I will discuss translational research strategies that leverage these insights to develop therapies targeting the molecular mechanisms underlying disease, thereby highlighting future directions for next-generation medical science that bridges basic research and clinical medicine.
– 参考文献
Takahashi M, et al. Nat Commun. 2026
Shintani-Domoto Y, et al. Circulation. 2025 Komuro J, et al. Nat Cardiovasc Res. 2025 Shinzato K, et al. Eur Heart J. 2025 Ito M, et al. Circulation. 2024 Katoh M, et al. Circulation. 2024 Yamada S, et al. Sci Adv. 2023 Miyazawa K, et al. Nat Genet. 2023 Yamada S, et al. Nat Cardiovasc Res. 2022 Ko T, et al. Nat Commun. 2022 Fujiwara T, et al. Circulation. 2021 Koyama S, et al. Nat Genet. 2020 Yamaguchi T, et al. Nat Commun. 2020 Nomura S, et al. Nat Commun. 2018