Title：“Transcription factor function in pluripotent and germline cells”

Ian Chambers, professor, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh

Abstract：

 Pluripotency is specified and maintained by cell-specific transcription factors, yet how such transcription factors operate remains incompletely understood. Here I discuss our work, focussing on the transcription factor NANOG and on embryonic stem cells and cells of the early germline. Our goal is to understand how transcription factors co-operate with partner proteins to modify transcription and regulate cell phenotype.