Tsuyoshi Osawa

Associate Professor, Research Center for Advanced Science and Technology, the University of Tokyo

– 講演タイトル

Cancer metabolism within the tumor microenvironments

– 抄録

Tumor microenvironments are critical for metabolic alteration thereby promoting tumor progression. However, how organelle dynamics controls cancer metabolism within the tumor microenvironments is not fully characterized to date. Here we demonstrate that Golgi and mitochondria dynamics may control cancer metabolism within the tumor microenvironments through comprehensive nutriomics analyses. Golgi disassembly was observed nutrient-starved cancer cells within the tumor microenvironment and stimulated golgi stress-mediated transcriptional activation. In addition, we found that acidic pH tumor microenvironment stimulated mitochondrial fission. We also found a novel mitochondrial fusion mechanism mediated by PIPs. Together, these results suggest the modulation of organelle dynamics within tumor microenvironments may become novel anti-cancer therapeutics to limit tumor progression.

– 参考文献

Hasegawa et al. Cell Rep 2026

Nakahara et al. EMBO J 2023

Pan et al. Nat Commun. 2022

Osawa et al. Cell Rep 2019

Kondo et al. Cell Rep 2017