– 発表者  福馬 伸章   Nobuaki Fukuma

Research Associate, Columbia university medical center, Faculty of medicine, Cardiology

– 講演タイトル

Forgotten no more: sex differences and right heart remodeling in heart failure

-The best thing you can do is the Right thing-

– 抄録

Despite decades of research works and expanded fields for heart failure research, the burden of heart failure has increased worldwide. As a key to unveil the heart failure mystery, I put the spotlight on the forgotten side of heart failure: the sex differences and right heart remodeling in heart failure. My presentation will cover the approach for assessing the female specific phenotypes and sex differences in the therapeutic effects for heart failure. Furthermore, talking about the trend in Columbia university, I focus on the right heart dysfunction contributing to heart failure, independent of lung or left heart remodeling. From the viewpoint of forgotten no more, I discuss how to connect the research questions from the bed side and the bench side.

– 参考文献　

1. Fukuma N, Tzimas C, Russo I, Dun W, Lance ML, Zhang Y, Kushner JS, Emala CW, Friebe A, Tucker NR, Tsai EJ. Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling; Circ Res. 2025 Dec 5;137(12):1407-1421.
2. Fukuma N, Tokiwa H, Numata G, Ueda K, Liu P, Tajima M, Otsu Y, Kariya T, Hiroi Y, James K. Liao, Komuro I, Takimoto E. Endothelial estrogen – myocardial cGMP axis critically determines angiogenesis and cardiac performance during pressure-overload. Cardiovasc Res. 2024 Dec 4;120(15):1884-1897.
3. Fukuma N, Liu P, Hiroi Y, Kunita A, Tokiwa H, Ueda K, Kariya T, Numata G, Adachi Y, Tajima M, Toyoda M, Li Y, Noma K, Harada M, Toko H, Ushiku T, Kanai Y, Takimoto E, James K. Liao, Komuro I. Tie2-Cre-Induced inactivation of non-nuclear estrogen receptor-α signaling abrogates estrogen protection against vascular injury. JACC Basic Transl Sci. 2022 Nov 16;8(1):55-67.
4. Fukuma N, Brener MI, Hulke ML, Golob S, Zilinyi RS, Zhou Z, Tzimas C, Russo I, McGroder C, Pfeiffer RD, Chong A, Zhang G, Burkhoff D, Leon MB, Maurer MS, Moses JW, Uhlemann AC, Hibshoosh H, Uriel N, Szabolcs MJ, Redfors B, Marboe CC, Baldwin MR, Tucker NR and Tsai EJ. Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19. JCI Insight. 2022;7.
5. Fukuma N, Takimoto E, Ueda K, Liu P, Tajima M, Otsu Y, Kariya T, Harada M, Toko H, Koga K, Blanton RM, Jr., Karas RH and Komuro I. Estrogen Receptor-alpha Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy. JACC Basic Transl Sci. 2020;5:282-295.