イベント&セミナー

[発生研セミナー] 12/2(月)11:00~ マギル大 藤田諒先生

2019.11.07 ●セミナー

第371回 発生研セミナー

 

 

【日時】 12月2日(月) 11:00~11:30
【会場】 発生医学研究所 1階カンファレンス室

 

【演題】 The adhesion G-protein coupled receptor GPR116 is required for muscle stem cell quiescence and self-renewal
【講師】 藤田 諒 Postdoctoral Fellow
Department of Human Genetics, McGill University

 

 

【要旨】
Regeneration of skeletal muscle largely depends on a resident pool of quiescent muscle stem cells (MuSCs), that normally reside underneath the basal lamina of myofibres, In response to muscle injury, MuSCs activate the myogenic program and enter the cell cycle in order to amplify a population of myogenic progenitors that either differentiate into new myofibers, or undergo self-renewal to maintain the MuSC pool. Facilitating endogenous repair could be a novel approach to treat muscle disease by harnessing the regenerative capacity of MuSCs, yet little is known about targetable pathways that regulate MuSC activity, which is especially true for the family of G protein coupled receptors (GPCRs) that are the pharmacological target of one third of all drugs. Here we show that Gpr116, a member of the adhesion GPCR family mediating cell-cell and cell-matrix interactions, is required for MuSC quiescence, self-renewal and long-term maintenance of the MuSC pool. Our characterization of adhesion GPR116 in MuSCs is a starting point to construct a more complete view of how MuSCs interact with their extracellular niche to regulate MuSC activity and to manipulate MuSCs in a therapeutic context. In this seminar, I will briefly share our recent findings including the downstream pathway of GPR116 and future directions of the study .

 

【連絡先】筋発生再生分野 小野 悠介(内線番号)6601

 

本セミナーは日本語で行われます。This seminar will be held in Japanese.

 

主催;熊本大学国際先端研究拠点
共催;トランスオミクス医学研究拠点ネットワーク形成事業