Division of Organogenesis
Department of Muscle Development and Regeneration

Original Articles

Yoshioka K, Nagahisa H, Miura F, Araki H, Kamei Y, Kitajima Y, Seko D, Nogami J, Tsuchiya Y, Okazaki N, Yonekura A, Ohba S, Sumita Y, Chiba K, Ito K, Asahina I, Ogawa Y, Ito T, Ohkawa Y, Ono Y*. Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. Science Advances. 2021 Jun 9. 7: eabd7924.


Fujimaki S, Ono Y*. Murine models of tenotomy-induced mechanical overloading and tail-suspension-induced mechanical unloading. Method Mol Biol. in press.


Yoshioka K, Kitajima Y, Seko D, Tsuchiya Y, Ono Y*. The body-region-specificity in murine models of muscle regeneration and atrophy. Acta Physiol. 2021 Jan;231(1):e13553. 

(NewPress: http://www.imeg.kumamoto-u.ac.jp/np111/)


Tsuchiya Y, Kitajima Y, Masumoto H, Ono Y*. Damaged myofiber-derived metabolic enzymes act as activators of muscle satellite cells. Stem Cell Rep. 2020 Oct 13;15(4):926-940.

(NewPress: http://www.imeg.kumamoto-u.ac.jp/np110/)  


Kitajima Y*, Suzuki N, Yoshioka K, Izumi R, Tateyama M, Tashiro Y, Takahashi R, Aoki M, Ono Y*. Inducible Rpt3, a proteasome component, knockout in adult skeletal muscle results in muscle atrophy. Front Cell Dev Biol. 2020 Sep 2;8:859.


Seko D#, Fujita R#, Kitajima Y, Nakamura K, Imai Y, Ono Y*. Estrogen receptor β controls muscle growth and regeneration in young female mice. Stem Cell Rep. 2020 Sep 8;15(3):577-586.

(NewPress: http://www.imeg.kumamoto-u.ac.jp/np109/)


Yoshioka K, Kitajima Y, Okazaki N, Chiba K, Yonekura A, Ono Y*. A Modified pre-plating method for high-yield and high-purity muscle stem cell isolation from human/mouse skeletal muscle tissues. Front Cell Dev Biol. 2020 Aug 13;8:793.


Yoshioka K, Fujita R, Seko D, Suematsu T, Miura S, Ono Y*. Distinct roles of Zmynd17 and PGC1α in mitochondrial quality control and biogenesis in skeletal muscle. Front Cell Dev Biol. 2019 Dec 10;7:330.


Uchitomi R, Hatazawa Y, Senoo N, Yoshioka K, Fujita M, Shimizu T, Miura S, Ono Y, Kamei Y*. Metabolomic analysis of skeletal muscle in aged mice. Sci Rep. 2019 Jul 18;9(1):10425. (発生研共同利用)


Kitajima Y*, Suzuki N, Nunomiya A, Osana S, Tashiro Y, Takahashi R, Ono Y*, Aoki M, Nagatomi R*. The Ubiquitin-proteasome system is indispensable for the maintenance of muscle stem cells. Stem Cell Rep 2018 Oct 25. pii: S2213-6711(18)30432-6.


Kitajima Y and Ono Y*. Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP-knock-in-mouse line. Skelet Muscle 2018 Aug 16.


Harada A#, Maehara K#, Ono Y, Taguchi H, Yoshioka K, Kitajima Y, Xie Y, Sato Y, Iwasaki T, Nogami J, Okada S, Komatsu T, Semba Y, Takemoto T, Kimura H, Kurumizaka H, Ohkawa Y*. Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration Nature Commun. 2018 Apr 11;9(1):1400.


Fujita R, Yoshioka K , Seko D, Suematsu T, Mitsuhashi S, Senoo N, Miura S, Nishino I, and Ono Y*. “Zmynd17 controls muscle mitochondrial quality and whole-body metabolism” FASEB Journal 2018 Sep;32(9):5012-5025. 2018


Hatazawa Y#, Ono Y#, Hirose Y, Kanai S, Fujii LN, Machida S, Nishino I, Shimizu T, Okano M, Kamei Y*, Ogawa Y*. Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. FASEB Journal. 2018 Mar;32(3):1452-1467.


Fujimaki S, Seko D, Y Kitajima, K Yoshioka, Tsuchiya Y, Masuda S, Ono Y*. Notch1 and Notch2 coordinately regulate muscle stem cell function in the quiescent and activated state. Stem Cells .2018 Feb;36(2):278-285.


Kitajima Y, Ogawa S, Egusa S, Ono Y*. Soymilk improves muscle weakness in young ovariectomized female mice. Nutrients 2017 Aug 4;9(8). pii: E834.


Kokabu S*, Nakatomi C, Matsubara T, Ono Y, Addison WN, Lowery JW, Urata M, Hudnall AM, Hitomi S, Nakatomi M, Sato T, Osawa K, Yoda T, Rosen V, Jimi E, A. TLE3 regulates myogenesis via repressing the transcriptional activity of MyoD. J Biol Chem. 2017 Aug 4;292(31):12885-12894.


Kawano F#*, Ono Y#, Fujita R, Watanabe A, Masuzawa R, Shibata K, Hasegawa S, Nakata K, Nakai N. Prenatal myonuclei play a crucial role for skeletal muscle hypertrophy in rodents. Am J Physiol Cell Physiol 2017 Mar 1;312(3):C233-C243.


Kitajima Y, Ogawa S and Ono Y*. Visualizing the functional heterogeneity in muscle stem cells. Methods Mol Biol. 2016 1516:183-93.


Kitajima Y and Ono Y*. Estrogens maintain skeletal muscle and satellite cell functions. J Endocrinol 2016 Jun. 229, 267–275.


Yamashita A, Hatazawa Y, Hirose Y, Ono Y, Kamei Y*. FOXO1 delays skeletal muscle regeneration and suppresses myoblast proliferation. Biosci Biotechnol Biochem 2016 Aug;80(8):1531-5.


Doi H, Kitajima Y, Lan L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS *. Potency of umbilical cord blood- and Wharton’s jelly-derived mesenchymal stem cells for scarless wound healing. Sci Rep 2016 Sci Rep. 2016 Jan 5;6:18844.


Seko D, Ogawa S, Li TS, Taimura A, Ono Y*. μ-Crystallin controls muscle function through thyroid hormone action. FASEB Journal. 2016 May;30(5):1733-40.


Manabe Y, Ogino S, Ito M, Furuichi Y, Takaga M, Yamada M, Goto-Inoue N, Ono Y, Fujii NL*. Evaluation of an in vitro muscle contraction model in mouse primary cultured myotubes. Anal Biochem. 2016 Mar 15;497:36-8.


Kitajima Y, Doi H, Ono Y, Urata Y, Goto S, Kitajima M, Miura K, Li TS*, Masuzaki H. Estrogen deficiency heterogeneously affects tissue specific stem cells in mice. Sci Rep 2015 Aug 6;5:12861


Masuda S#, Hisamatsu T#, Seko S#, Urata Y, Goto S, Li TS, Ono Y*. Time- and dose-dependent effects of total-body ionising radiation on muscle stem cells. Physiol Reports, 3 (4), 2015, e12377.


Ono Y*, Urata Y, Goto S, Nakagawa S, Humbert PO, Li TS, Zammit PS. Muscle stem cell fate is controlled by the cell polarity protein Scrib. Cell Reports, 2015 Feb 24;10(7):1135-48.


Guo CW, Luo L, Urata Y, Goto S, Hunag WJ, Takamura S, Hayashi F, Doi H, Kitajima Y, Ono Y, Ogi T, Li TS*. Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice. Sci Rep. Jan 27;5:8055, 2015.


Tanaka T*, Li T, Urata Y, Goto S, Ono Y, Kawakatsu M, Matsushima H, Hirabaru M, Adachi T, Kitasato A, Takatsuki M, Kuroki T, Eguchi S. Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to the poor neovascularization in pancreatic ductal adenocarcinoma, J Gastroenterol, 2015 Sep;50(9):975-83.


Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS*. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. Biochem Biophys Res Commun. 2014 Sep 26;452(3):548-53.


Urata Y, Goto S, Luo L, Doi H, Kitajima Y, Masuda S, Ono Y, Li TS*. Enhanced Nox1 expression and oxidative stress resistance in c-kit-positive hematopoietic stem/progenitor cells. Biochem Biophys Res Commun. 2014 Oct 24;454(3):376-380.


Luo L, Kawakatsu M, Guo CW, Urata Y, Huang WJ, Ali H, Doi H, Kitajima Y, Tanaka T, Goto S, Ono Y, Xin HB, Hamano K, Li TS*. Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells. Sci Rep. 2014 Jan 21;4:3779.


Guo CW, Kawakatsu M, Idemitsu M, Urata Y, Goto S, Ono Y, Hamano K, Li TS*. Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells. J Cell Physiol. 2013 Nov;228(11):2159-66.


Kawakatsu M, Urata Y, Goto S, Ono Y, Li TS*. Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity. J Radiat Res. 2013 Mar 1;54(2):268-76.


Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS*. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One 2013;8(3):e60023.


Ono Y*, Masuda S, Nam HS, Benezra R, Miyagoe-Suzuki Y, Takeda S. Slow-dividing satellite cells retain long-term self-renewal ability in adult muscle” J Cell Sci. 2012 Mar 1;125(Pt 5):1309-17.


Wang B, Miyagoe-Suzuki Y, Yada E, Ito N, Nishiyama T, Nakamura M, Ono Y, Segawa M, Motohashi N, Masuda S, and Takeda S*. Reprogramming efficiency and quality of induced Pluripotent Stem Cells (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages. PLoS Curr. 2011 Oct 27;3:RRN1274.


Ono Y, Calbaheu F, Morgan JE, Katagiri T, Amthor H, Zammit PS*. BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells. Cell Death Differ. 2011 Feb;18(2):222-34.


Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, Katagiri T*. Suppression of BMP-Smad Signaling Axis-Induced Osteoblastic Differentiation by Small C-terminal Domain Phosphatase 1, a Smad Phosphatase. Mol Endoclenol. 2011 Mar;25(3):474-81.


Ono Y, Boldrin L, Knopp P, Morgan J, Zammit PS*. Muscle satellite cells are a functionally heterogeneous population in both somite-derived and branchiomeric muscles. Dev Biol. 2010 Jan 1;337(1):29-41.


Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, Yada E, Kanesaki H, Miyagoe-Suzuki Y, Takeda S, Kawakami K*. Six family genes control the proliferation and differentiation of muscle satellite cells. Exp Cell Res. 2010 Oct 15;316(17):2932-44.


Gnocchi VF, White R, Ono Y, Ellis J, Zammit PS*. Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells. PLOS ONE. 2009; 2009;4(4):e5205.


Ono Y*, Gnocchi VF, Zammit PS, Nagatomi R. Presenilin-1 acts via Id1 to regulate muscle satellite cell function in a gamma-secretase independent manner. J Cell Sci. 2009 Dec 15;122(Pt 24):4427-38.


Matsuo K, Zhang X, Ono Y, Nagatomi R*. Acute stress-induced colonic tissue HSP70 expression requires commensal bacterial components and intrinsic glucocorticoid. Brain Behav Immun. 2009 Jan 23(1):108-15.


Okada A*, Ono Y, Nagatomi R, Kishimoto KN, Itoi E. Decreased muscle atrophy F-box (MAFbx) expression in regenerating muscle after muscle-damaging exercise. Muscle Nerve. 2008 Oct;38(4): 1246-53.


Ono Y, Sensui H, Okutsu S, Nagatomi R*. Notch2 negatively regulates myofibroblastic differentiation of myoblasts. J Cell Physiol. 2007 Feb;210(2):358-69.


Ono Y, Sensui H, Sakamoto Y, Nagatomi R*. Knockdown of hypoxia-inducible factor-1alpha by siRNA inhibits C2C12 myoblast differentiation. J Cell Biochem. 2006 Jun 1;98(3):642-9.



Review Articles/Book Chapters

Fujimaki S and Ono Y*. Notch signaling in the regulation of skeletal muscle stem cells. J Phys Fitness Sports Med 7(4): 213-219, 2018.


Fujita R, Seko S, Ono Y*. Scribble dictates orderly stem cell fate. Oncotarget 2015, Vol. 6, No.22.18738-9.


Fujita R and Ono Y*. eIF2α, a potential target for stem cell-based therapies. Stem Cell Investig 2016 Jul 22;3:30.


Ono Y*. Satellite cell heterogeneity and hierarchy in skeletal muscle. J Phys Fitness Sports Med 3(2): 229-234, 2014.


Ono Y*. Stem cell hierarchies in muscle satellite cells. “Basic Biology and Current Understanding of Skeletal Muscle” NOVA Biomedical. Chapter1.p1-19, 2013.


Ono Y*. New Insights into Muscle Stem Cells. “Current Research on Skeletal Muscle”. Research Signpost. Chapter1.pp1-18. 2011.



Ⅲ. Review Articles/Book Chapters (in Japanese)

小野悠介「カヘキシアにおけるサルコペニアと液性因子」医学のあゆみ, 274巻6・7号. 2020年8月.


中村晃大,小野悠介「顔面肩甲上腕型筋ジストロフィーの基礎研究の現状」難病と在宅ケア Vol.25 No.8, 10-14. 2019年12月.


林晋一郎,小野悠介「骨格筋からのサテライト細胞の単離法」実験医学増刊 Vol.36 No.7 2018年4月.


吉岡潔志,小野悠介「がん悪液質の身体部位特異的な筋応答」 基礎老化研究. 2017年10月.


北島百合子,江草信太郎, 小野悠介「女性アスリートの三主徴とエストロゲン欠乏が骨格筋に与える影響」 日本スポーツ栄養学会誌. 2017 .1


吉岡潔志,小野悠介「サテライト細胞の部位特異性と筋の肥大・萎縮」 体育の科学.2016年9月.


瀬古大暉,小川静香,小野悠介「サテライト細胞と細胞極性」基礎老化研究. 巻:40 (1) 19-25, 2016.


小野悠介「筋サテライト細胞の不均一性」生体の科学Vol.64 No.2, 2013.


小野悠介「運動生理学(分担執筆)」三共出版 2013年.


小野悠介「再生医療事業の課題解決のための手引書(分担執筆)」技術情報協会出版 2013年.


小野悠介「骨格筋部位特異的なサテライト細胞の性質と加齢による変容」基礎老化研究. 巻:36 (3) 51-53,2012.