Division of Stem Cell Research
Department of Cell Differentiation

Publications from 2002


Tsuji-Tamura, K. and M. Ogawa. FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2. Angiogenesis 26: 523-545, 2023. DOI: 10.1007/s10456-023-09884-7
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Yokomizo, T., T. Ideue, S. Morino-Koga, C. Y. Tham, T. Sato, N. Takeda, Y. Kubota, M. Kurokawa, N. Komatsu, M. Ogawa, K. Araki, M. Osato and T. Suda. Independent origins of fetal liver hematopoietic stem and progenitor cells. Nature 609: 779-784, 2022. DOI: 10.1038/s41586-022-05203-0


Tsuruda, M., S. Morino-Koga and M. Ogawa.
Hematopoietic stem cell-independent differentiation of mast cells from mouse intraembryonic VE-cadherin+ cells.
Stem Cells, DOI: 10.1093/stmcls/sxac001
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Tsuruda, M., S. Morino-Koga and M. Ogawa.
Bone morphogenetic protein 4 differently promotes distinct VE-cadherin+ precursor stages during the definitive hematopoietic development from embryonic stem cell-derived mesodermal cells.
Exp. Hematol. 103: 40-51.e7, 2021. DOI: 10.1016/j.exphem.2021.08.008


Tsuji-Tamura, K., S. Morino-Koga, S. Suzuki and M. Ogawa.
The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis.
J. Cell Sci. 134 (15): jcs254920, 2021. DOI: 10.1242/jcs.254920


Tsuji-Tamura, K. and M. Ogawa. Morphology regulation in vascular endothelial cells. Inflammation and Regeneration 38:25, 2018. DOI: 10.1186/s41232-018-0083-8.


Tsuji-Tamura, K. and M. Ogawa. Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation. Biochem. Biophys. Res. Commun. 497: 326-331, 2018.


Ahmed, T., K. Tsuji-Tamura and M. Ogawa. CXCR4 signaling negatively modulates the bipotential state of hemogenic endothelial cells derived from embryonic stem cells by attenuating the endothelial potential. Stem Cells 34: 2814-2824, 2016.


Nakajima, M., M. Ogawa, Y. Amakura, M. Yoshimura, S. Okuyama and Y. Furukawa. 3,5,6,7,8,3’,4’-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of mice. Biomed. Res. (Tokyo) 37: 95-99, 2016.


Tsuji-Tamura, K. and M. Ogawa. Inhibition of the PI3K/Akt and mTORC1 signaling pathways promotes the elongation of vascular endothelial cells. J. Cell Sci. 129: 1165-1178, 2016.


Hirota, S. and M. Ogawa. Activin A in combination with OP9 cells facilitates development of Flk-1+ PDGFRα- and Flk-1+ PDGFRα+ hematopoietic mesodermal cells from murine embryonic stem cells. Biochem. Biophys. Res. Commun. 467: 583-588, 2015.


Sakamoto, H., N. Takeda, F. Arai, K. Hosokawa, P. Garcia, T. Suda, J. Frampton and M. Ogawa. Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Stem Cells 33: 479-490, 2015.


Taguchi, A., Y. Kaku, T. Ohmori, S. Sharmin, M. Ogawa, H. Sasaki and R. Nishinakamura. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14: 53-67, 2014.



Tan, K. S., K. Tamura, M. Lai, A. Veerakumarasivam, Y. Nakanishi, M. Ogawa and D. Sugiyama. Molecular pathways governing development of vascular endothelial cells from ES/iPS cells. Stem Cell Rev. and Rep. 9: 586-598, 2013.


Ishida, M., O. El-Mounayri, S. Kattman, P. Zandstra, H. Sakamato, M. Ogawa, G. Keller and M. Husain. Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells. Circ. Res. 110: 253-264, 2012.


Tsuji-Tamura, K., H. Sakamoto and M. Ogawa. ES cell differentiation as a model to study cell biological regulation of vascular development. ‘Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis’ ed. Craig Atwood, ISBN 978-953-307-196-1, INTECH, Vienna, Austria, 2011, pp581-606.


Kulkeaw, K., Y. Horio, C. Mizuochi, M. Ogawa and D. Sugiyama. Variation in hematopoietic potential of induced pluripotent stem cell lines. Stem Cell Rev. and Rep. 6: 381-389, 2010.

Sakamoto, H., K. Tsuji-Tamura and M. Ogawa. Hematopoiesis from pluripotent stem cell lines (Review). Int. J. Hematol. 91: 384-391, 2010.


Kondo, N., M. Ogawa, H. Wada and S-I. Nishikawa. Thrombin induces rapid disassembly of claudin-5 from the tight junction of endothelial cells. Exp. Cell Res. 315: 2879-2887, 2009.

Park, S., H. Sakamoto, K. Tamura, T. Furuyama and M. Ogawa. Foxo1 is essential for in vitro vascular formation from embryonic stem cells. Biochem. Biophys. Res. Commun. 390: 861-866, 2009.


Matsukawa, M., H. Sakamoto, M. Kawasuji, T. Furuyama and M. Ogawa. Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology. Genes Cells 14: 1167-1181, 2009.


Huang, X., H. Sakamoto and M. Ogawa. Thrombopoietin controls proliferation of embryonic multipotent hematopoietic progenitors. Genes Cells 14: 851-860, 2009.


Hashimoto, K., T. Fujimoto, Y. Shimoda, X. Huang, H. Sakamoto and M. Ogawa. Distinct hemogenic potentials of endothelial cells and CD41+ cells in the mouse embryos. Dev. Growth Differ. 49:287-300, 2007.


Yokomizo, T., S. Takahashi, N. Mochizuki, T. Kuroha, M. Ema, A. Wakamatsu, R. Shimizu, O. Ohneda, M. Osato, H. Okada, T. Komori, M. Ogawa, S-I. Nishikawa, Y. Ito and M. Yamamoto. Characterization of GATA-1 + hemangioblastic cells in the mouse embryo. EMBO J. 26: 184-196, 2007.


Guo, R., H. Sakamoto, S. Sugiura and M. Ogawa. Endothelial cell motility is compatible with junctional integrity. J. Cell. Physiol. 211: 327-335, 2007.


Sugiyama, D. , M. Ogawa, K. Nakao, N. Osumi, S. Nishikawa, S-I. Nishikawa, K-I. Arai, T. Nakahata and K. Tsuji. B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency. Dev. Biol. 301: 53-61, 2007.


Dai, G., H. Sakamoto, Y. Shimoda, T. Fujimoto, S-I. Nishikawa and M. Ogawa. Over-expression of c-Myb increases the frequency of hemogenic precursors in the endothelial cell population. Genes Cells 11: 859-870, 2006.


Sakamoto, H., G. Dai, K. Tsujino, K. Hashimoto, X. Huang, T. Fujimoto, M. Mucenski, J. Frampton and M. Ogawa. Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development. Blood 108: 896-903, 2006.


Kogata, N., Y. Arai, J.T. Pearson, K. Hashimoto, K. Hidaka, T. Koyama, S. Somekawa, Y. Nakaoka, M. Ogawa, R.H. Adams, M. Okada and N. Mochizuki. Cardiac ischemia activates vascular endothelial cadherin promoter in both pre-existing vascular cells and bone marrow cells involved in neovascularization. Circ. Res. 98: 897-904, 2006.


Nakajima, M., M. Ogawa, Y. Shimoda, S. Hiraoka, M. Iida, H. Koseki, T. Shirasawa and K. Furukawa. Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its b-catenin-binding region. Cell Biol. Int. 30: 239-243, 2006.


Hisatsune, H., K. Matsumura, M. Ogawa, A. Uemura, N. Kondo, J. K. Yamashita, H. Katsuta, S. Nishikawa, T. Chiba and S-I. Nishikawa. High level of endothelial cell-specific gene expression by a combination of the 5′ flanking region and the 5′ half of the first intron of the VE-cadherin gene. Blood 105: 4657-4663, 2005.


Furuyama, T., K. Kitayama, Y. Shimoda, M. Ogawa, K. Sone, K. Yoshida-Araki, H. Hisatsune, S-I. Nishikawa, K. Nakayama, K. Nakayama, K. Ikeda, N. Motoyama and N. Mori. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279: 34741-34749, 2004.


Sakamoto, H., X. Zhang, S. Suenobu, K. Ohbo, M. Ogawa and T. Suda. Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity. Biochem. Biophys. Res. Commun. 321: 681-687, 2004.


Sugiyama, D., M. Ogawa, I. Hirose, T. Jaffredo, K-I. Arai and K. Tsuji. Erythropoiesis from acetyl LDL incorporating endothelial cells at the pre-liver stage. Blood 101: 4733-4738, 2003.


Schroeder, T., S. Fraser, M. Ogawa, S. Nishikawa, C. Oka, G. Bornkamm, S-I. Nishikawa, T. Honjo and U. Just. Recombination signal sequence-binding protein Jk alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc. Natl. Acad. Sci. USA 100: 4018-4023, 2003.


Fraser, S., M. Ogawa, T. Yokomizo, Y. Ito, S. Nishikawa and S-I. Nishikawa. Putative intermediate precursor between hematogenic endothelial cells and blood cells in the developing embryo. Develop. Growth Differ. 45: 63-75, 2003.


Yurugi-Kobayashi, T., H. Itoh, J. Yamashita, K. Yamahara, H. Hirai, T. Kobayashi, M. Ogawa, S. Nishikawa, S-I. Nishikawa and K. Nakao. Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stages. Blood 101: 2675-2678, 2003.


Hidaka, K., J-K. Lee, H. S. Kim, C. H. Ihm, A. Iio, M. Ogawa, S-I. Nishikawa, I. Kodama and T. Morisaki. Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells. FASEB J. 17: 740-742, 2003.


Hirashima, M, M. Ogawa, S. Nishikawa, K. Matsumura, K. Kawasaki, M. Shibuya and S-I. Nishikawa. A chemically defined culture of VEGFR2+ cells derived from embryonic stem cells revealed the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells. Blood 101: 2261-2267, 2003.


Matsumura, K., M. Hirashima, M. Ogawa, H. Kubo, H. Hisatsune, N. Kondo, S. Nishikawa, T. Chiba and S-I. Nishikawa. Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3. Blood 101: 1367-1374, 2003.


Hirai, H., M. Ogawa, N. Suzuki, M. Yamamoto, G. Breier, O. Mazda, J. Imanishi and S-I. Nishikawa. Hemogenic and non-hemogenic endothelium can be distinguished by the activity of fetal liver kinase (Flk)-1 promoter/enhancer during mouse embryogenesis. Blood 101: 886-893, 2003.


Endoh, M., M. Ogawa, S. Orkin and S-I. Nishikawa. SCL/tal-1 dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. EMBO J. 21: 6700-6708, 2002.


Uemura, A., M. Ogawa, M. Hirashima, T. Fujiwara, S. Koyama, H. Takagi, Y. Honda, S. J. Wiegand, G. D. Yancopoulos and S-I. Nishikawa. Recombinant angiopoietin-1 restores higher order architecture on growing blood vessels in absence of mural cells. J. Clin. Invest. 110: 1619-1628, 2002.


Fraser, S., M. Ogawa, R. Yu, S. Nishikawa, M. Yoder and S-I. Nishikawa. Definitive hematopoietic commitment within the embryonic vascular endothelial-cadherin+ population. Exp. Hematol. 30: 1070-1078, 2002.


Miyashita, H., T. Yamazaki, T. Akada, O. Niizeki, M. Ogawa, S-I. Nishikawa and Y. Sato. A mouse orthologue of puromycin insensitive leucyl-specific aminopeptidase (PILSAP) is expressed in endothelial cell and plays an important role in angiogenesis. Blood 99: 3241-3249, 2002.


Fraser, S., M. Ogawa, S. Nishikawa and S-I. Nishikawa. Embryonic stem cell differentiation as a model to study hematopoietic and endothelial cell development. Methods in Molecular Biology 185: 71-81, 2002.