{"id":2159,"date":"2010-05-12T20:31:41","date_gmt":"2010-05-12T11:31:41","guid":{"rendered":"https:\/\/www.imeg.kumamoto-u.ac.jp\/en\/?p=2159"},"modified":"2016-03-29T14:20:50","modified_gmt":"2016-03-29T05:20:50","slug":"global-coe-mini-symposium-may-12-2010","status":"publish","type":"post","link":"https:\/\/www.imeg.kumamoto-u.ac.jp\/en\/global-coe-mini-symposium-may-12-2010\/","title":{"rendered":"Global COE Mini Symposium May 12, 2010"},"content":{"rendered":"

Global COE Mini Symposium
\n<\/strong>\u201cAnalysis of nervous system functions in model organisms and its potential research applications\u201d<\/h2>\n

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\u3010 Date <\/strong>\u3011 Wednesday, May 12, 2010 13:00 – 16:10<\/strong><\/p>\n

\u3010 Venue <\/strong>\u3011 Conference Room, <\/strong>IMEG <\/strong>1F<\/strong><\/p>\n

\u3010 Invited Speaker <\/strong>\u3011 Nobuki Nakanishi, PhD. (Sanford-Burnham Medical <\/strong>Research Institute)
\n<\/strong>\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000\u3000Yuichi Iino, <\/strong>PhD. ( Tokyo <\/strong>University <\/strong>of <\/strong>Tokyo <\/strong>)<\/strong><\/p>\n

\n

\u3010 Program <\/strong>\u3011<\/p>\n

13:00-13:30 Daisuke Matsumaru Global COE Jr.RA Department of Organ Formation
\n<\/strong>\u201cGenetic analysis of Hedgehog signaling for the ventral body wall development and the onset of omphalocele formation.\u201d<\/p>\n

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13:30-14:00 Minoru Kawakami Assistant Professor Department of Phylogeny
\n<\/strong>\u201cEffects of cyclosporin A administration on gene expression in rat brain.<\/p>\n

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14:00-15:00 Nobuki <\/strong>Nakanishi <\/strong>Associate Professor <\/strong>Center <\/strong>for Neuroscience, Aging and <\/strong>Stem Cells<\/strong>Sanford-Burnham Medical Research Institute
\n<\/strong>\u201cGenetic analysis of mice lacking the NR3A subunit of NMDA receptors\u201d<\/p>\n

\n\u3014 <\/strong>Summary <\/strong>\u3015 <\/strong>Glutamate is the major excitatory neurotransmitter in mammalian brain. NMDA-type glutamate receptors (NMDARs) are thought to act as integrators of coincident synaptic signals, while their hyperactivation causes neurodegeneration. The conventional NMDAR requires two distinct subunits,
\nNR1 and NR2, to form functional channels. We and others have identified a third family of NMDAR subunits, designated NR3. Through the analyses of NR3A knockout (KO) and transgenic mice, we have shown that NR3A acts as an inhibitory subunit of NMDARs. Furthermore, we have identified a large gene family named takusan, whose expression is upregulated in NR3A KO
\nmice. Biochemical and cellular studies reveal that takusan plays a role in the organization of postsynaptic molecules. We currently explore whether takusan proteins can be exploited as therapeutic agents combating neurodegenerative diseases such as Alzheimer’s.<\/p>\n

\n

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15:00-15:10 \u226a <\/strong>Break <\/strong>\u226b<\/strong><\/p>\n

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15:10-16:10 Yuichi Iino <\/strong>Professor <\/strong>Molecular Genetics Research Laboratory University <\/strong>of <\/strong>Tokyo
\n<\/strong>\u3000\u201cMolecular mechanisms of salt chemotaxis learning in C. elegans <\/em>\u201d
\n\u3014 Summary \u3015 <\/strong>The nametode C. elegans has 302 neurons and its entire neural circuit is known. It also allows forward genetic screening to isolate behavioral mutants. The chemotaxis behavior of this animal is plastic. For example, C. elegans raised under standard conditions shows positive chemotaxis to NaCl. However, when it is kept with NaCl but without food, it now learns to avoid NaCl. Through analyses of mutants defective in this form of learning (salt chemotaxis learning), we found that the insulin\/PI 3-kinase signaling pathway is essential for learning. The Gq\/DAG\/nPKC pathway was found to act antagonistically to the insulin pathway. Mutants in the homologue of calsyntenin, which is abundant in mammalian brain, was also found to be defective in learning. I will describe the molecular and neural mechanisms of learning along with the behavioral strategy of chemotaxis.<\/p>\n

Organizer : Kenichi Yamamura, Minoru Kawakami, IMEG
\nContact Information: Global COE Promotion Office Ikuko Yamaguchi (Ext.5006)<\/p>\n","protected":false},"excerpt":{"rendered":"

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