Division of Organogenesis
Department of Germline Development

Publications (present – 2001)


Google Scholar: https://scholar.google.co.jp/citations?user=w8jue18AAAAJ&hl=ja
ORCID: http://orcid.org/0000-0001-6506-9146
Researchmap: https://researchmap.jp/read0118144/



*Sano, H., Nakamura, A., Yamane, M., Niwa, H., Nishimura, T., Araki, K., Takemoto, K., Ishiguro, K., Aoki, H., Kato, Y. and Kojima, M. (2022). The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. PLOS Biol. 20, e3001678.
doi: 10.1371/journal.pbio.3001678


Pushpalatha, K., Solyga, M., Nakamura, A. and *Besse, F. (2022). RNP components condense into repressive RNP granules in the aging brain. Nat. Commun. 13, 2782.
doi: 10.1038/s41467-022-30066-4


Buddika, K., Huang, Y.-T., Butrum-Griffith, A., Norrell, S. A., O’Conner, A. M., Patel, V. K., Rector, S. A., Slovan, M., Sokolowsky, M., Kato, Y., Nakamura, A. and *Sokol, N. S. (2022). Coordinate transcriptional and post-transcriptional repression of pro-differentiation genes maintains intestinal stem cell identity. Curr. Biol. 32, 386-397.
doi: 10.1016/j.cub.2021.11.032


De Graeve, F., Formicola, N., Pushpalatha, K., Nakamura, A., Debreuve, E., Descombes, X., and Besse, F. (2022). Detecting Stress Granules in Drosophila neurons. In: Methods in Molecular Biology vol2428: The Integrated Stress Response. (D. Mateju and J. A. Chao eds). Humana, New York, NY, pp229-242.
doi: 10.1007/978-1-0716-1975-9_14


Yoshinari, Y., Kosakamoto, H., Kamiyama, T., Hoshino, R., Matsuoka, R., Kondo, S., Tanimoto, H., Nakamura, A., Obata, F. and *Niwa, R. (2021). The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster. Nat. Commun. 12, 4818.
doi: 10.1038/s41467-021-25146-w


Singh, C. R., Glineburg, M. R., Moore, C., Tani, N., Jaiswal, R., Zou, Y., Aube, E., Gillaspie, S., Thornton, M., Cecil, A., Hilgers, M., Takasu, A., Asano, I., Asano, M., Escalente, C., Nakamura, A., Todd, P. and *Asano, K. (2021). Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism. Cell Rep. 36, 109376.
doi: 10.1016/j.celrep.2021.109376


Formicola, N., Heim, M., Dufourt, J., Lancelot, A.-S., Nakamura, A., Lagha, M. and *Besse, F. Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain. eLife e65742.


*Tanaka, T., Tani, N. and *Nakamura, A. Receptor-mediated yolk uptake is required for oskar mRNA localization and cortical anchorage of germ plasm components in the Drosophila oocyte. PLOS Biol. 19, e3001183.


Yamamoto, M., Suwa, Y., Sugiyama, K., Okashita, N., Tani, N., Kawaguchi, M., Matsubara, K., Nakamura, A. and *Seki Y. PRDM14-CtBP1/2-PRC2 complex regulates transcriptional repression during transition from primed to naïve pluripotency. J. Cell Sci. jcs240176.


Kamiyama, T., Sun, W., Tani, N., Nakamura, A. and *Niwa, R. (2020). Poly(A) Binding Protein is required for nuclear localization of the ecdysteroidogenic transcription factor Molting defective in the prothoracic gland of Drosophila melanogaster. Front. Genet. 11, 636.


Koiwai, K., Inaba, K., Morohashi, K., Enya, S., Arai, R., Kojima, H., Okabe, T., Fujisawa, Y., Inoue, H., Yoshino, R., Hirokawa, T., Kato, K., Fukuzawa, K., Shimada-Niwa, Y., Nakamura, A., Yumoto, F., Senda, T. and *Niwa, R. (2020). An integrated approach to unravel a crucial structural property for the function of the insect steroidogenic Halloween protein Noppera-bo. J. Biol. Chem. 295, 7154-7167.


*Asaoka, M., Hanyu-Nakamura, K., Nakamura, A. and *Kobayashi, S. (2019). Maternal Nanos inhibits Importin-α2/Pendulin–dependent nuclear import to prevent somatic gene expression in the Drosophila germline. PLOS Genet. 15, e1008090.



Kina, H., Yoshitani, T., Hanyu-Nakamura, K. and *Nakamura, A. (2019). Rapid and Efficient generation of GFP-knocked-in Drosophila by the CRISPR-Cas9-mediated genome editing. Develop. Growth Differ. 61, 265-275.
doi: 10.1111/dgd.12607.
・The cover article of the issue.

・Young Investigator Paper Award 2020


Hanyu-Nakamura, K., Matsuda, K., Cohen, S. M. and *Nakamura, A. (2019). Pgc suppresses the zygotically-acting RNA decay pathway to protect germ plasm RNAs in the Drosophila embryo. Development dev.167056. 
doi: 10.1242/dev.167056.


*Kikuchi, K., Nakamura, A., Arata, M., Shi, D., Nakagawa, M., Tanaka, T., Uemura, T., Fujimori, T., Kikuchi, A., Uezu, A., Sakamoto, Y. and *Nakanishi, H. (2018). Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling. EMBO Rep. e45471.
doi: 10.15252/embr.201745471


Yamane, M., Ohtsuka, S., Matsuura, K., Nakamura, A., Okano, M. and *Niwa, H. (2018). Overlapping functions of Krüppel-like factor family members: targeting multiple transcription factors to maintain naïve pluripotency of mouse embryonic stem cells. Development 145, dev162404.
doi: 10.1242/dev.162404.
•Featured in the “Research Highlight” section of the issue.


*Niwa, H., Nakamura, A., Urata, M., Shirae-Kurabayashi, M., Kuraku, S. and Ohtsuka, S. (2016). The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells. BMC Evol. Biol. 16, 173.
doi: 10.1186/s12862-016-0755-4


Liu, G., Sanghavi, P., Bollinger, K. E., Perry, L., Marshall, B., Roon, P., Tanaka, T., Nakamura, A. and *Gonsalvez, G. B. (2015). Efficient endocytic uptake and maturation in Drosophila oocytes requires Dynamitin/p50. Genetics 201, 631-649. doi:10.1534/genetics.115.180018.


*Sano, H., Nakamura, A., Texada, M., Truman, J. W., Ishimoto, H., Kamikouchi, A., Nibu, Y., Kume, K., Ida, T. and Kojima, M. (2015). The nutrient-responsive hormone CCHamide-2 controls growth by regulating insulin-like peptides in the brain of Drosophila melanogaster. PLOS Genet. 11, e1005209.
doi: 10.1371/journal.pgen.1005209.


Kim, G., Pai, C.-I., Sato, K., Person, M. D., Nakamura, A. and *Macdonald, P. M. (2015). Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression. PLOS Genet. 11, e1004992.
doi: 10.1371/journal.pgen.1004992.


Tsai, Y. C., Chang, W., Liou, W., Lee, W. H., Chang, Y. W., Wang, P. Y., Tanaka, T., Nakamura, A. and *Pai, L. M. (2014). Endophilin B is required for the Drosophila oocyte to endocytose yolk downstream of Oskar. Development 141, 563-573.
doi: 10.1242/dev.097022.


Pradhan, S. J., Nesler, K. R., Rosen, S. F., Kato, Y., Nakamura, A., Ramaswami, M. and *Barbee, S. A. (2012). The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction. J. Cell Sci. 125, 6105-6116.
doi: 10.1242/jcs.113043.


Kato, Y. and *Nakamura, A. (2012). Roles of cytoplasmic RNP granules in intracellular RNA localization and translational control in the Drosophila oocyte. Develop. Growth Differ. (review article) 54, 19-31.
doi: 10.1111/j.1440-169X.2011.01314.x.


*Tanaka, T. and *Nakamura, A. (2011). Oskar-induced endocytic activation and actin remodeling for anchorage of the Drosophila germ plasm. BioArchitecture (Perspective review article) 1, 122-126.
doi: 10.4161/bioa.1.3.17313.


*Shirae-Kurabayashi, M., Matsuda, K. and *Nakamura, A. (2011). Ci-Pem-1 localizes to the nucleus and represses somatic gene transcription in the germline of Ciona intestinalis embryos. Development 138, 2871-2881. 
doi: 10.1242/dev.058131.
•The cover article of the issue. 
•Featured in the “Highlight” section in Biology of Reproduction.


Tanaka, T, Kato, Y., Hanyu-Nakamura, K., Matsuda, K. and *Nakamura, A. (2011). Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. Development 138, 2523-2532. 
doi: 10.1242/dev.062208.
•Highlighted in the “In This Issue” section.
•Featured in the “Highlights” in Nature Cell Biology.


Yamada, K., Fuwa, T., Ayukawa, T., Tanaka, T., Nakamura, A., Baron, M. and *Matsuno, K. (2011). Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation. Genes Cells 16, 261-272. 
doi: 10.1111/j.1365-2443.2011.01488.x.


*Nakamura, A., Shirae-Kurabayashi, M. and Hanyu-Nakamura, K. (2010). Repression of early zygotic transcription in the germline. Curr. Opin. Cell Biol. (review article) 22, 709-714. 
doi: 10.1016/j.ceb.2010.08.012.


Abe, M., Setoguchi, Y., Tanaka, T., Awano, W., Takahashi, K., Ueda, R., Nakamura, A. and *Goto, S. (2009). Membrane protein localization-dependent regulation by PI3K(III) and Rabenosyn-5 in Drosophila wing cells. PLoS ONE 4, e7306.
doi: 10.1371/journal.pone.0007306.


*Nakamura, A. and *Seydoux, G. (2008). Less is more: specification of the germline by transcriptional repression. Development (review article) 135, 3817-3827.
doi: 10.1242/dev.022434.


Aratani, S., Kageyama, Y., Nakamura, A., Fujita, H., Fujii, R., Nishioka, K. and *Nakajima, T. (2008). MLE activates transcription via the minimal transactivation domain in Drosophila. Int. J. Mol. Med. 21, 469-476.
doi: 10.3892/ijmm.21.4.469.


Tanaka, T. and *Nakamura, A. (2008). The endocytic pathway acts downstream of oskar in Drosophila germ plasm assembly. Development 135, 1107-1117. 
doi: 10.1242/dev.017293.
•Highlighted in the “In This Issue” section. 
•Cited over 100 times (Google Scholar).


Hanyu-Nakamura, K., Sonobe-Nojima, H., Tanigawa, A., Lasko, P. and *Nakamura, A. (2008). Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells. Nature 451, 730-733.
doi: 10.1038/nature06498.
• Cited over 100 times (Google Scholar).


Barbee, S. A., Estes, P. S., Cziko, A.-M., Hillebrand, J., Luedeman, R. A., Coller, J. M., Johnson, N., Howlett, I. C., Geng, C., Ueda, R., Brand, A. H., Newbury, S. F., Wilhelm, J. E., Levine, R. B., *Nakamura, A., *Parker, R. and *Ramaswami, M. (*corresponding authors) (2006). Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P-bodies. Neuron 52, 997-1009.
•Cited over 300 times (Google Scholar).


*Shirae-Kurabayashi, M. , Nishikata, T., Takamura, K., Tanaka, K.J., Nakamoto, C. and *Nakamura, A. (2006). Dynamic redistribution of vasa homolog and exclusion of somatic cell determinants during germ cell specification in Ciona intestinalis. Development 133, 2683-2693. 
doi: 10.1242/dev.02446.
•Cover article of the issue. 
•Selected in the “In This Issue” section.


Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S. and *Yokoyama, S. (2006). Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa. Cell 125, 287-300. 
•Selected for “Previews” section.
•Cited over 450 times (Google Scholar).


Boag, P. R., Nakamura, A. and *Blackwell, T. K. (2005). A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans. Development 132, 4975-4986. 
doi: 10.1242/dev.02060.
•Selected for “In This Issue” section. 
•Cited over 100 times (Google Scholar).


Hanyu-Nakamura, K., Kobayashi, S. and *Nakamura, A. (2004). Germ cell-autonomous Wunen2 is required for germline development in Drosophila embryos. Development 131, 4545-4553. 
doi: 10.1242/dev.01321.
•Selected for “In This Issue” section.


*Nakamura, A., Sato, K. and Hanyu-Nakamura, K. (2004). Drosophila Cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis. Dev. Cell 6, 69-78. 
•Highlighted in the “In Brief” in Nat Rev. Mol. Cell Biol.
•Cited over 300 times (Google Scholar).


Sengoku, T., Nureki, O., Dohmae, N., Takio, K., Nakamura, A. Kobayashi, S. and *Yokoyama, S. (2004). Crystallization and preliminary X-ray analysis of the helicase domains of Vasa complexed with RNA and an ATP analogue. Acta Cryst. D60, 320-322.


Kawashima, T., Nakamura, A., Yasuda, K. and *Kageyama, Y. (2003). Dmaf, a novel member of Maf transcription factor family is expressed in somatic gonadal cells during embryonic development and gametogenesis in Drosophila. Gene Expr. Pat. 3, 663-667.


Styhler, S., Nakamura, A. and *Lasko, P. (2002). VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. Dev. Cell 3, 865-876.


Inoue, B.S., Shimoda, M., Nishinokubi, I., Siomi, M., Okamura, M., Nakamura, A., Kobayashi, S., Ishida, N. and *Siomi, H. (2002). A role for the Drosophila fragile X-related gene in circadian output. Curr. Biol. 12, 1331-1335.
•Cited over 100 times (Google Scholar).


Sano, H., Nakamura, A. and *Kobayashi, S. (2002). Identification of a transcriptional regulatory region for germline-specific expression of vasa in Drosophila melanogaster. Mech. Dev. 112, 129-139.


Nakamura, A., Amikura, R., Hanyu, K. and *Kobayashi, S. (2001). Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. Development 128, 3233-3242.
•Cited over 200 times (Google Scholar).


Amikura, R., Kashikawa, M., Nakamura, A. and *Kobayashi, S. (2001). Presence of mitochondria-type ribosomes outside mitochondria in germ plasm of Drosophila embryos. Proc. Natl. Acad. Sci. USA 98, 9133-9138.



Review Article

1. Kato, Y. and Nakamura, A. (2012). Roles of cytoplasmic RNP granules in intracellular RNA localization and translational control in the Drosophila oocyte. Develop. Growth Differ. 54, 19-31.


2. Tanaka, T.* and Nakamura, A. (2011). Oskar-induced endocytic activation and actin remodeling for anchorage of the Drosophila germ plasm. BioArchitecture 1, 122-126.


3. Nakamura, A., Shirae-Kurabayashi, M. and Hanyu-Nakamura, K. (2010). Repression of early zygotic transcription in the germline. Curr. Opin. Cell Biol. 22, 709-714.


4. Nakamura, A. and Seydoux, G. (2008). Less is more: specification of the germline by transcriptional repression. Development 135, 3817-3827.