【Date】 Nov. 16 (Fri), 2018 15:00～16:00
【Venue】Conference room, 1st floor, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University
【Abstract】
The epigenetic mechanisms of germ cells are ultimately responsible for the perpetuity of life. To elucidate the epigenetic mechanisms that govern mammalian germ cells, we focus on how the epigenome is preset (poised) for gene regulation in subsequent stages of differentiating germ cells. The major transition in spermatogenesis is the mitosis-to-meiosis transition. Recently, we identified two major enhancers that govern this transition. While superenhancers drive robust expression of spermatogenesis genes, endogenous retroviruses function as enhancers and drive species-specific transcriptomes. Furthermore, by performing Hi-C (genome-wide chromosome conformation capture), we reveal the 3D chromatin organization of male germ cells from the meiotic stage to sperm. These chromatin characteristics undergo progressive strengthening and consolidation to form an abundance of constrained topological associated domains (TADs) in mature sperm. I will introduce our recent progress.
【Contact】Dept. of Chromosome Biology, Ki-ichiro Ishiguro (Ext. 6606)
共催：熊本大学国際先端研究拠点
