イベント&セミナー

[発生研セミナー] 3月24日15:00~熊本保健科学大 田中聡先生

2017.03.23 ●セミナー

The 308th IMEG Seminar

 

【Date】 Mar. 24 (Fri), 2017 15:00~16:00
【Venue】Conference room, 1st floor,
Institute of Molecular Embryology and Genetics (IMEG),
Kumamoto University

 

【Title】Molecular networks underlying gonadal formation, germ cell formation and sex determination in mice

 

【Speaker】Satomi S. Tanaka, Ph.D.
Associate Professor
Department of Rehabilitation,
Faculty of Health Science,
Kumamoto Health Science University

 

 

【Abstract】
To generate the next generation, male or female gametes develop in a testis or ovary for the sexual reproduction. The genital ridge, a gonadal primordium, is composed of somatic cells and germ cells that give rise to male or female gametes. These two lineages are formed at different developmental stages and positions in the embryo. A ratio of two numbers, germ cell and gonadal somatic cell number is considered to be crucial for gonadal development. For example, a threshold number of germ cells is required for stabilizing the ovarian fate in zebrafish (Tzung et al., 2014). However, mechanisms that regulate numbers of germ cells and gonadal somatic cells remain to be unclear.
Six family proteins (from Six1 to Six6) are transcriptional factors with characteristic Six- and homeo -domains. Among the family, Six1 and Six4 have redundant functions in mouse embryonic development, through transactivation of common target genes by binding to a common binding sequence (MEF3 site). We previously found that Loss of Six1 and Six4, but neither alone, resulted in a male-to-female sex reversal phenotype in XY-mutant mouse gonads (Fujimoto et al., 2013). Interestingly, Six1 and Six4 also regulate the progenitor cell pool size in the formation of both germ cell and gonadal somatic cell lineages. Six1 and Six4 therefore contribute to the molecular networks that underlay gonadal formation, germ cell formation and sex determination in mice. In this seminar, molecular mechanisms of Six1 and Six4 in sex determination and the regulation of the progenitor pool size of gonads will be discussed.

 

【Contact】Dept. of Kidney Development, Ryuichi Nishinakamura (Ext. 6615)

 

このセミナーは「発生医学の共同研究拠点」の一環として行われます。