Title:
Regulation of cellular metabolism in vivo by hypoxic response

Department of Biochemistry, School of Medicine, Keio University / Suematsu Gas Biology Project, ERATO, JST
Yoji Andrew Minamishima, M.D., Ph.D.

Abstract:
Hypoxic response, the cellular response against an environment where available oxygen is limited, is mainly regulated by heterodimeric transcriptional factor HIF (hypoxia-inducible factor), whose activity is negatively regulated by prolyl hydroxylase PHDs (PHD1~3). In this context, PHDs behaves as “oxygen sensors” and inactivation of PHDs displays constitutively activated hypoxic response.
 HIF-dependent hypoxic response is involved in various cellular events including erythropoiesis, neovascularization or regulation of energy metabolism.
 We’ve focused on how HIF-dependent hypoxic response regulates metabolism in vivo, not in vitro or in cellulo, and here we discuss how glucose, lactate or other metabolites are regulated by hypoxic response in vivo.