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リエゾンラボ研究会
発表内容

Title:
The role of vasohibin family in the regulation of angiogenesis

Yasufumi SATO
Department of Vascular Biology
Institute of Development, Aging and Cancer, Tohoku University

Abstract:
 The vascular system is one of the most quiescent organs in the body, but has the capacity to form neo-vessels as necessary. This process, known as angiogenesis, occurs in various pathophysiological conditions including cancers. The local balance between angiogenesis stimulators and inhibitors are thought to determine the occurrence, progress and termination of angiogenesis. We have isolated vasohibin-1 (VASH1) as a novel angiogenesis inhibitor synthesized preferentially by endothelial cells (ECs), and vasohibin-2 (VASH2) as its homologue. VASH1 and VASH2 are more than 50% homologous in their amino acid sequences and highly conserved between species. Our subsequent analyses have revealed that VASH1 is induced in ECs and terminates angiogenesis, whereas VASH2 is barely detected under basal condition but is expressed not in ECs but in certain cell types including cancers and stimulates angiogenesis. The significance of vasohibins in pathophysiological conditions will be discussed in the seminar.

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