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リエゾンラボ研究会
発表内容

Title:
Role of environmental factors in systemic autoimmunity

Minoru Satoh, MD, PhD
Professor
Department of Clinical Nursing
School of Health Sciences
University of Occupational and Environmental Health , Japan

Abstract:
Production of autoantibodies and the development of autoimmune diseases are mediated by interaction of genetic factors and environmental factors. A variety of environmental factors that can trigger and affect progression and severity of autoimmune diseases, including environmental toxin, weather, food, medication, virus, bacteria and others, are known. Some of these factors are extensively investigated using established animal models while pathogenesis of autoimmunity by others are poorly understood. Mechanisms of antigen-specific autoimmunity may include modification and overexpression of a particular autoantigen, which may lead to breaking immunological tolerance and developing autoimmune disease. Potential roles of environmental factors in human and animal autoimmune diseases will be discussed focusing on the effects of adjuvant hydrocarbon oils and other xenobiotics.

References:
1. Reeves WH, Lee PY, Weinstein JS, Satoh M, Lu L: Induction of autoimmunity by pristane and other naturally occurring hydrocarbons. Trends Immunol 2009, 30:455-464.

2. Kuroda Y, Nacionales DC , Akaogi J, Reeves WH, Satoh M: Autoimmunity induced by adjuvant hydrocarbon oil components of vaccine. Biomed Pharmacother 2004, 58:325-337.

3. Koppang EO, Bjerkas I, Haugarvoll E, Chan EK, Szabo NJ, Ono N, Akikusa B, Jirillo E, Poppe TT, Sveier H, Torud B, Satoh M: Vaccination-induced systemic autoimmunity in farmed Atlantic salmon. J Immunol 2008, 181:4807-4814.

4. Satoh M, Chan EK, Ho LA, Rose KM, Parks CG, Cohn RD, Jusko TA, Walker NJ, Germolec DR, Whitt IZ, Crockett PW, Pauley BA, Chan JY, Ross SJ, Birnbaum LS, Zeldin DC, Miller FW: Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012, 64:2319-2327.

5. Satoh M, Vazquez-Del Mercado M, Chan EK: Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases. Mod Rheumatol 2009, 19:219-228.